Document Detail

Reduced thrombospondin-1 at presentation predicts disease progression in superficial bladder cancer.
MedLine Citation:
PMID:  12429155     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: Superficial bladder cancer (SBC) presents a difficult clinical dilemma at diagnosis as only a small subgroup of patients will subsequently develop invasive disease. Study of cancer biology has found that angiogenesis is central to growth and spread. This study examines the relationship between the angiogenic inhibitory factor Thrombospondin-1 (TSP-1) at initial presentation and subsequent progression of SBC. METHODS: Using immunohistochemistry, 220 cases of SBC were examined for pattern and extent of expression of TSP-1 at initial presentation. RESULTS: TSP-1 was detected in perivascular tissue, at the epithelial-stromal junction, in the stroma and in tumour cells and reduced perivascular TSP-1 staining at presentation was an independent predictive factor for the subsequent development of muscle invasive or metastatic disease. CONCLUSION: This adds further weight to the theory that TSP-1 plays a major part in the biology of bladder cancer possibly through the control of angiogenesis.
Jonathan Charles Goddard; Christopher Derek Sutton; Janet Louise Jones; Kenneth John O'Byrne; Roger Clive Kockelbergh
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European urology     Volume:  42     ISSN:  0302-2838     ISO Abbreviation:  Eur. Urol.     Publication Date:  2002 Nov 
Date Detail:
Created Date:  2002-11-13     Completed Date:  2003-06-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7512719     Medline TA:  Eur Urol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  464-8     Citation Subset:  IM    
Department of Urology, University Hospitals of Leicester NHS Trust, Leicester LE1 5WW, UK.
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MeSH Terms
Aged, 80 and over
Disease Progression
Middle Aged
Multivariate Analysis
Neoplasm Invasiveness
Thrombospondin 1 / metabolism*
Tumor Markers, Biological / metabolism*
Urinary Bladder Neoplasms / metabolism*,  pathology,  surgery
Reg. No./Substance:
0/Thrombospondin 1; 0/Tumor Markers, Biological

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