Document Detail

Reduced third-trimester levels of soluble human leukocyte antigen G protein in severe preeclampsia.
MedLine Citation:
PMID:  17826409     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Recently, lower maternal plasma human leukocyte antigen (HLA)-G protein levels in preeclampsia (PE) in the first and second trimester was reported. Thus, we sought to evaluate the levels of HLA-G protein in patients with severe PE during the third trimester. STUDY DESIGN: In this prospective case control study, amniotic fluid and maternal and cord blood samples were aspirated from 50 pregnant women during the third trimester. The study group included 26 pregnant women diagnosed with severe PE and 24 women without PE serving as controls. A soluble HLA-G-specific enzyme-linked immunosorbent assay was used to measure protein levels. Statistical analysis included the Student t test and simple regression analysis. RESULTS: Maternal serum HLA-G levels in PE pregnancies were found to be significantly lower as compared with normal pregnancies (10.97 +/- 6.55 vs 36.05 +/- 34.53 microg/mL; P = .003). CONCLUSION: A reduced level of maternal HLA-G protein was associated with severe PE during the third trimester. This finding may suggest an essential role for HLA-G in normal and preeclamptic pregnancies.
Rinat Hackmon; Arie Koifman; Hironobu Hyodo; Hirohito Hyobo; Hagit Glickman; Eyal Sheiner; Daniel E Geraghty
Related Documents :
9141549 - Inhibin a and activin a in the first trimester of human pregnancy.
7515839 - Immunolocalization and expression of insulin-like growth factor i (igf-i) in the mammar...
1256729 - Human placental lactogen and intrauterine growth retardation.
10632669 - Variations in cytokine mrna expression during normal human pregnancy.
20629489 - Prooxidant-antioxidant balance in pregnancy: a randomized double-blind placebo-controll...
6193519 - Direct evidence for interaction between human erythroid progenitor cells and a hemoglob...
18512229 - Association of syndromic mental retardation with an xq12q13.1 duplication encompassing ...
7826499 - Macrophage inflammatory protein-1 alpha in term and preterm parturition: effect of micr...
1062909 - Iron absorption in early pregnancy - a study of the absorption of non-haeme iron and fe...
Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  197     ISSN:  1097-6868     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2007 Sep 
Date Detail:
Created Date:  2007-09-10     Completed Date:  2007-09-19     Revised Date:  2008-02-20    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  255.e1-5     Citation Subset:  AIM; IM    
Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Amniotic Fluid / chemistry
Case-Control Studies
Fetal Blood / chemistry
HLA Antigens / blood*
Histocompatibility Antigens Class I / blood*
Pre-Eclampsia / blood*
Pregnancy Trimester, Third / blood
Prospective Studies
Grant Support
Reg. No./Substance:
0/HLA Antigens; 0/HLA-G antigen; 0/Histocompatibility Antigens Class I
Erratum In:
Am J Obstet Gynecol. 2008 Feb;198(2):245
Note: Hyobo, Hirohito [corrected to Hyodo, Hironobu]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Are women who have had a preterm twin delivery at greater risk of preterm birth in a subsequent sing...
Next Document:  Stillbirths in an urban community in Pakistan.