Document Detail


Reduced third-trimester levels of soluble human leukocyte antigen G protein in severe preeclampsia.
MedLine Citation:
PMID:  17826409     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Recently, lower maternal plasma human leukocyte antigen (HLA)-G protein levels in preeclampsia (PE) in the first and second trimester was reported. Thus, we sought to evaluate the levels of HLA-G protein in patients with severe PE during the third trimester. STUDY DESIGN: In this prospective case control study, amniotic fluid and maternal and cord blood samples were aspirated from 50 pregnant women during the third trimester. The study group included 26 pregnant women diagnosed with severe PE and 24 women without PE serving as controls. A soluble HLA-G-specific enzyme-linked immunosorbent assay was used to measure protein levels. Statistical analysis included the Student t test and simple regression analysis. RESULTS: Maternal serum HLA-G levels in PE pregnancies were found to be significantly lower as compared with normal pregnancies (10.97 +/- 6.55 vs 36.05 +/- 34.53 microg/mL; P = .003). CONCLUSION: A reduced level of maternal HLA-G protein was associated with severe PE during the third trimester. This finding may suggest an essential role for HLA-G in normal and preeclamptic pregnancies.
Authors:
Rinat Hackmon; Arie Koifman; Hironobu Hyodo; Hirohito Hyobo; Hagit Glickman; Eyal Sheiner; Daniel E Geraghty
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  197     ISSN:  1097-6868     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2007 Sep 
Date Detail:
Created Date:  2007-09-10     Completed Date:  2007-09-19     Revised Date:  2008-02-20    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  255.e1-5     Citation Subset:  AIM; IM    
Affiliation:
Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA. rhackmon@gmail.com
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MeSH Terms
Descriptor/Qualifier:
Amniotic Fluid / chemistry
Case-Control Studies
Female
Fetal Blood / chemistry
HLA Antigens / blood*
Histocompatibility Antigens Class I / blood*
Humans
Pre-Eclampsia / blood*
Pregnancy
Pregnancy Trimester, Third / blood
Prospective Studies
Grant Support
ID/Acronym/Agency:
R01 HD045813/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/HLA Antigens; 0/HLA-G antigen; 0/Histocompatibility Antigens Class I
Comments/Corrections
Erratum In:
Am J Obstet Gynecol. 2008 Feb;198(2):245
Note: Hyobo, Hirohito [corrected to Hyodo, Hironobu]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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