| Reduced thalamic volume in patients with chronic schizophrenia after switching from typical antipsychotic medications to olanzapine. | |
| | |
MedLine Citation:
|
PMID: 17074955 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: The authors performed a longitudinal study of the effects on thalamic volume of switching from typical to atypical antipsychotic medications. METHOD: Magnetic resonance imaging scans were acquired from 10 subjects with chronic schizophrenia taking typical antipsychotics and 20 healthy volunteers. Subjects with schizophrenia were switched to olanzapine; both groups were rescanned. RESULTS: At baseline, thalamic volumes in subjects with chronic schizophrenia were 5.8% greater than those of healthy volunteers. At follow-up, there was no significant difference between groups. Additional analysis revealed a significant positive correlation between baseline thalamic volume and dosage of typical antipsychotic medication. Higher dosages at baseline were correlated with larger reductions in volume after the switch to olanzapine. CONCLUSIONS: Antipsychotic medication effects may be a factor in the wide range of thalamic volume differences reported between subjects with schizophrenia and healthy volunteers. |
| | |
Authors:
|
Babak Khorram; Donna J Lang; Lili C Kopala; Robert A Vandorpe; Qing Rui; Vina M Goghari; Geoffrey N Smith; William G Honer |
Related Documents
:
|
15170765 - Refill rate of antipsychotic drugs: an easy and inexpensive method to monitor patients'... 19933955 - Meta-analysis of the impact of 9 medication classes on falls in elderly persons. 7893845 - Quantitative electrophysiological characteristics and subtyping of schizophrenia. 12407275 - Medical comorbidity and receipt of medical care by older homeless people with schizophr... 16842515 - Factors associated with attitude and hypothetical behaviour regarding brain death and o... 16528435 - Prudent layperson definition of an emergent pediatric medical condition. |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: The American journal of psychiatry Volume: 163 ISSN: 0002-953X ISO Abbreviation: Am J Psychiatry Publication Date: 2006 Nov |
Date Detail:
|
Created Date: 2006-10-31 Completed Date: 2007-01-10 Revised Date: 2008-11-21 |
Medline Journal Info:
|
Nlm Unique ID: 0370512 Medline TA: Am J Psychiatry Country: United States |
Other Details:
|
Languages: eng Pagination: 2005-7 Citation Subset: AIM; IM |
Affiliation:
|
Centre for Complex Disorders, VGH Research Pavilion, Rm. 203-828 West 10th Ave., Vancouver, BC, Canada V5Z 1L8. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Antipsychotic Agents / adverse effects*, therapeutic use Atrophy Benzodiazepines / adverse effects, therapeutic use Chlorpromazine / adverse effects, therapeutic use Chronic Disease Female Follow-Up Studies Humans Hypertrophy Longitudinal Studies Magnetic Resonance Imaging Male Schizophrenia / drug therapy*, pathology* Thalamus / drug effects, pathology* Therapeutic Equivalency |
| Chemical | |
Reg. No./Substance:
|
0/Antipsychotic Agents; 12794-10-4/Benzodiazepines; 132539-06-1/olanzapine; 50-53-3/Chlorpromazine |
| Comments/Corrections | |
Erratum In:
|
Am J Psychiatry. 2006 Dec;163(12):2199 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: An inverse relationship between perceived harm and participation willingness in schizophrenia resear...
Next Document: Voxelwise correlational analyses of white matter integrity in multiple cognitive domains in schizoph...