| Reduced stress- and cold-induced increase in energy expenditure in interleukin-6-deficient mice. | |
| | |
MedLine Citation:
|
PMID: 16455769 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Interleukin-6 (IL-6) deficient (-/-) mice develop mature onset obesity. Pharmacological studies have shown that IL-6 has direct lipolytic effects and when administered centrally increases sympathetic outflow. However, the metabolic functions of endogenous IL-6 are not fully elucidated. We aimed to investigate the effect of IL-6 deficiency with respect to cold exposure and cage-switch stress, that is, situations that normally increase sympathetic outflow. Energy metabolism, core temperature, heart rate, and activity were investigated in young preobese IL-6-/- mice by indirect calorimetry together with telemetry. Baseline measurements and the effect of cage-switch stress were investigated at thermoneutrality (30 degrees C) and at room temperature (20 degrees C). The effect of cold exposure was investigated at 4 degrees C. At 30 degrees C, the basal core temperature was 0.6 +/- 0.24 degrees C lower in IL-6-/- compared with wild-type mice, whereas the oxygen consumption did not differ significantly. The respiratory exchange ratio at 20 degrees C was significantly higher and the calculated fat utilization rate was lower in IL-6-/- mice. In response to cage-switch stress, the increase in oxygen consumption at both 30 and 20 degrees C was lower in IL-6-/- than in wild-type mice. The increase in heart rate was lower in IL-6-/- mice at 30 degrees C. At 4 degrees C, both the oxygen consumption and core temperature were lower in IL-6-/- compared with wild-type mice, suggesting a lower cold-induced thermogenesis in IL-6-/- mice. The present results indicate that endogenous IL-6 is of importance for stress- and cold-induced energy expenditure in mice. |
| | |
Authors:
|
Ingrid Wernstedt; Amanda Edgley; Anna Berndtsson; Jenny Fäldt; Göran Bergström; Ville Wallenius; John-Olov Jansson |
Related Documents
:
|
21845049 - Histological study of the biodynamics of iron oxide nanoparticles with different diamet... 8950209 - Differential production of interleukin-6 and its close relation to liver metastasis in ... 8131749 - Interleukin-6 deficient mice are protected from bone loss caused by estrogen depletion. 1378269 - Enhancement of il-6 receptor beta chain (gp130) expression by il-6, il-1 and tnf in hum... 16550359 - Interleukin-6 promotes human epidermal keratinocyte proliferation and keratin cytoskele... 9028389 - Is tnf really involved in cachexia? 14969999 - Mutations in the extracellular loop of alpha-renac alter sensitivity to amiloride and r... 3961809 - Fate of erythrocyte cd-metallothionein in mice. 17194489 - Differential susceptibility following beta-amyloid peptide-(1-40) administration in c57... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: American journal of physiology. Regulatory, integrative and comparative physiology Volume: 291 ISSN: 0363-6119 ISO Abbreviation: Am. J. Physiol. Regul. Integr. Comp. Physiol. Publication Date: 2006 Sep |
Date Detail:
|
Created Date: 2006-08-29 Completed Date: 2006-09-20 Revised Date: 2008-11-21 |
Medline Journal Info:
|
Nlm Unique ID: 100901230 Medline TA: Am J Physiol Regul Integr Comp Physiol Country: United States |
Other Details:
|
Languages: eng Pagination: R551-7 Citation Subset: IM |
Affiliation:
|
Research Centre for Endocrinology and Metabolism, Sahlgrenska University Hospital, Gothenburg, Sweden. Ingrid.Wernstedt@medic.gu.se |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Cold Temperature* Energy Metabolism / genetics, physiology* Female Interleukin-6 / deficiency*, genetics, metabolism* Male Mice Mice, Knockout Norepinephrine / blood Stress, Physiological / physiopathology* Thermogenesis / physiology |
| Chemical | |
Reg. No./Substance:
|
0/Interleukin-6; 51-41-2/Norepinephrine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Interleukin-1 mediates endothelin-1-induced fever and prostaglandin production in the preoptic area ...
Next Document: Regulation of components of the brain and cardiac renin-angiotensin systems by 17beta-estradiol afte...