Document Detail

Reduced spinal bone density in young women with amenorrhoea.
MedLine Citation:
PMID:  1834488     Owner:  NLM     Status:  MEDLINE    
To assess the influence of diminished oestrogen production on bone density, we studied 23 amenorrhoeic women and 20 controls (age range 16-29 years) divided into four groups: group 1: 6 patients with idopathic hypogonadotrophic hypogonadism with primary amenorrhoea (IHH); group 2: 5 patients with delayed puberty owing to thalassaemia major (TM); group 3: 12 patients with secondary hypothalamic amenorrhoea (HA); group 4: 20 women with normal menses (controls). Secondary sexual characteristics had developed in all except the women with TM. Groups 1 and 2 had never menstruated and group 3 had been amenorrhoeic for 6 months to 3 years. The control group was studied during the follicular phase of the cycle. None of the patients were taking oestrogens at the time of observation. Plasma concentrations were determined for 17 beta-oestradiol (E2), deidroepiandrosterone sulphate (DHEA-S), cortisol (F), prolactin (PRL), thyroid hormones (T3 and T4), and gonadotrophins (LH and FSH). Spinal bone mineral density (BMD g/cm2) was assessed by dual photon absorbiometry. BMD (mean +/- 1SD) was reduced in the patients (group 2: 0.920 +/- 0.95; group 1: 0.980 +/- 0.94; and group 3: 1.037 +/- 0.75) as compared with the controls (1.290 +/- 0.95) (P less than 0.01). In the three groups of patients, plasma E2 levels were lower than 50 pg/ml and were positively correlated with the BMD. As expected, plasma gonadotrophin levels were highly and significantly reduced (P less than 0.01) in the patients, compared with that of the controls. These results suggest that reduced spinal BMD in hypogonadic women may be related to the lack of oestrogenic influence on bone metabolism.(ABSTRACT TRUNCATED AT 250 WORDS)
G Fabbri; F Petraglia; A Segre; A Maietta-Latessa; M C Galassi; M Cellini; S Sardelli; F Massolo; A Genazzani; A R Genazzani
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of obstetrics, gynecology, and reproductive biology     Volume:  41     ISSN:  0301-2115     ISO Abbreviation:  Eur. J. Obstet. Gynecol. Reprod. Biol.     Publication Date:  1991 Sep 
Date Detail:
Created Date:  1991-12-20     Completed Date:  1991-12-20     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0375672     Medline TA:  Eur J Obstet Gynecol Reprod Biol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  117-22     Citation Subset:  IM    
Department of Obstetrics and Gynaecology, University of Modena, Italy.
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MeSH Terms
Amenorrhea / complications*,  physiopathology
Bone Density*
Dehydroepiandrosterone / blood
Estradiol / blood
Hydrocortisone / blood
Luteinizing Hormone / blood
Osteoporosis / complications*,  physiopathology
Prolactin / blood
Spinal Diseases / complications*,  physiopathology
Thyroid Hormones / blood
Reg. No./Substance:
0/Thyroid Hormones; 50-23-7/Hydrocortisone; 50-28-2/Estradiol; 53-43-0/Dehydroepiandrosterone; 9002-62-4/Prolactin; 9002-67-9/Luteinizing Hormone

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