Document Detail


Reduced sodium concentration and increased sodium-potassium pump activity of erythrocytes in human hypertension.
MedLine Citation:
PMID:  2439453     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Erythrocyte Nai, Nai/Ki and ouabain-sensitive and ouabain-insensitive 86Rb uptake (K transport) were measured in whole blood of 16 normotensive and 19 hypertensive white male subjects, within seconds or minutes after withdrawal of blood. Erythrocyte Nai and Nai/Ki were reduced (p less than 0.05), and ouabain-sensitive 86Rb uptake was increased (p less than 0.01) in hypertensive subjects. In a separate group of hypertensive white male subjects, an inverse correlation was found between erythrocyte Nai/Ki and ouabain-binding sites per erythrocyte (r = 0.85, p less than 0.01, n = 9). The abnormalities of erythrocyte cation fluxes in hypertensive subjects are similar to those induced by aldosterone in vascular smooth muscle cells and by glucocorticoid administration in the erythrocytes of human subjects, suggesting similarities in pathogenesis.
Authors:
G Simon; C R Engel
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Hypertension     Volume:  9     ISSN:  0194-911X     ISO Abbreviation:  Hypertension     Publication Date:  1987 Jun 
Date Detail:
Created Date:  1987-08-05     Completed Date:  1987-08-05     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  III13-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Binding Sites
Erythrocytes / metabolism*
Humans
Hypertension / blood*
Ion Channels / physiology*
Male
Osmolar Concentration
Ouabain / metabolism,  pharmacology
Potassium / metabolism*
Radioisotopes / blood
Reference Values
Rubidium / blood
Sodium / blood*,  metabolism
Grant Support
ID/Acronym/Agency:
HL34400/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Ion Channels; 0/Radioisotopes; 630-60-4/Ouabain; 7440-09-7/Potassium; 7440-17-7/Rubidium; 7440-23-5/Sodium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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