Document Detail

Reduced short latency afferent inhibition in patients with Down syndrome and Alzheimer-type dementia.
MedLine Citation:
PMID:  16931146     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Adults with Down syndrome (DS) develop progressive cognitive impairment resembling the cognitive profile of Alzheimer's disease (AD). Although the specific neurobiological correlates of cognitive deficits in DS are still not completely understood, it has been proposed that cholinergic dysfunction may contribute to some of these deficits in DS who develop AD. A recently devised test of motor cortex excitability, the short latency afferent inhibition (SAI), has been proven to be helpful in exploring some cholinergic circuits of the human brain. The authors used this test to assess the involvement of the cholinergic transmission in the DS. METHODS: We evaluated the SAI in 12 patients with DS and in 15 healthy subjects. RESULTS: SAI was significantly reduced in DS patients when compared with the controls; the values correlated with the patient's age and the score on Dementia Scale for Down Syndrome. SAI was increased after administration of a single dose of donezepil in a subgroup of 5 patients. CONCLUSIONS: Our findings suggest that, with respect to this putative marker of central cholinergic activity, dementia in aging DS shares pathophysiological similarities to AD in the general population. SIGNIFICANCE: This technique may help to clarify the pathophysiological basis of cognitive dysfunction in DS and may represent an additional tool for the diagnosis of Alzheimer-type dementia in subjects with DS.
R Nardone; R Marth; H Ausserer; A Bratti; F Tezzon
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Publication Detail:
Type:  Journal Article     Date:  2006-08-22
Journal Detail:
Title:  Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology     Volume:  117     ISSN:  1388-2457     ISO Abbreviation:  Clin Neurophysiol     Publication Date:  2006 Oct 
Date Detail:
Created Date:  2006-09-14     Completed Date:  2006-12-15     Revised Date:  2008-09-10    
Medline Journal Info:
Nlm Unique ID:  100883319     Medline TA:  Clin Neurophysiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  2204-10     Citation Subset:  IM    
Department of Neurology - F. Tappeiner Hospital - Merano (BZ), Via Rossini, 5, 39012 Merano (BZ), Italy.
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MeSH Terms
Alzheimer Disease / complications*,  physiopathology*
Brain / drug effects,  physiopathology
Cholinesterase Inhibitors / pharmacology
Down Syndrome / complications*,  physiopathology*
Indans / pharmacology
Middle Aged
Neural Inhibition / physiology*
Piperidines / pharmacology
Transcranial Magnetic Stimulation
Reg. No./Substance:
0/Cholinesterase Inhibitors; 0/Indans; 0/Piperidines; 120011-70-3/donepezil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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