Document Detail

Reduced serum proteins in diabetic children on a twice-daily insulin schedule.
MedLine Citation:
PMID:  3911725     Owner:  NLM     Status:  MEDLINE    
The concentrations of selected proteins of transport and nutrition were investigated in 27 diabetic children and 13 healthy controls by an immunodiffusion technique. The diabetic children had significantly lower mean pre-albumin (p less than 0.001), albumin (p less than 0.01) and orosomucoid levels (p less than 0.05) than the healthy controls. No correlation was observed between age or sex and the blood concentrations of the specific proteins analyzed in this series. Haptoglobin and hemopexin showed positive correlations with serum triglycerides (both p less than 0.01) and slight positive correlations with some of the variables of carbohydrate control. The reduced levels of prealbumin and albumin were not correlated to diabetic control as measured by HbA1, fasting plasma glucose or urinary glucose excretion. The non-physiological distribution site and the abnormal temporal pattern of insulin offered to diabetic children might be the reason for the protein abnormalities found in this study. This is seemingly the first time reduced serum levels of proteins have been reported in diabetic children.
M Gebre-Medhin; U Ewald; T Tuvemo
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta paediatrica Scandinavica     Volume:  74     ISSN:  0001-656X     ISO Abbreviation:  Acta Paediatr Scand     Publication Date:  1985 Nov 
Date Detail:
Created Date:  1986-03-13     Completed Date:  1986-03-13     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0000211     Medline TA:  Acta Paediatr Scand     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  961-5     Citation Subset:  IM    
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MeSH Terms
Age Factors
Blood Proteins / metabolism*
Diabetes Mellitus, Type 1 / blood*
Energy Metabolism / drug effects
Insulin / administration & dosage*
Nutritional Physiological Phenomena / drug effects
Sex Factors
Reg. No./Substance:
0/Blood Proteins; 11061-68-0/Insulin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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