Document Detail

Reduced serum cholecystokinin and increase in body fat during oral contraception.
MedLine Citation:
PMID:  8838488     Owner:  NLM     Status:  MEDLINE    
This investigation was undertaken to explore a possible role of the "satiety peptide" cholecystokinin and some other gastrointestinal hormones for changes in appetite and weight during oral contraception. Ten young healthy women attending a youth health care center for contraceptive counseling volunteered for the study. A standardized meal test was used for recordings of appetite and gastrointestinal hormone response before and after 5 months of treatment with a monophasic combined oral contraceptive. Body fat was calculated from measurements of skin-fold thickness. Oral contraceptives caused a suppression of basal levels of serum cholecystokinin, which was correlated to an increase in body fat. Meal-related response of cholecystokinin and appetite were not affected. Serum levels of gastrin and insulin were also unchanged, whereas triglycerides and postprandial glucose levels were elevated. The results suggest a role of cholecystokinin in regulation of body composition. Cholecystokinin stimulates the release of insulin and stimulates lipolysis in adipose tissue. Reduced cholecystokinin levels may, therefore, be related to mild impairment of glucose tolerance and promote body fat storage during oral contraception.
A L Hirschberg; B Byström; K Carlström; B von Schoultz
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Contraception     Volume:  53     ISSN:  0010-7824     ISO Abbreviation:  Contraception     Publication Date:  1996 Feb 
Date Detail:
Created Date:  1996-12-02     Completed Date:  1996-12-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0234361     Medline TA:  Contraception     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  109-13     Citation Subset:  IM; J    
Department of Obstetrics, Karolinska Hospital, Stockholm, Sweden.
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MeSH Terms
Adipose Tissue*
Blood Glucose / metabolism
Body Composition*
Cholecystokinin / blood*
Contraceptives, Oral / adverse effects*
Gastrins / blood
Insulin / blood
Skinfold Thickness
Triglycerides / blood
Reg. No./Substance:
0/Blood Glucose; 0/Contraceptives, Oral; 0/Gastrins; 0/Triglycerides; 11061-68-0/Insulin; 9011-97-6/Cholecystokinin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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