| Reduced retinal vessel response to flicker stimulation but not to exogenous nitric oxide in type 1 diabetes. | |
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MedLine Citation:
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PMID: 19369238 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: Various studies have shown that retinal vessels in patients with diabetes mellitus have a reduced capacity to adapt to changes in perfusion pressure and to stimulation with flickering light. Structural and functional changes in retinal vessels in diabetes could lead to a general reduction of vasodilator and/or vasoconstrictor capacity. To gain more insight into this topic, we compared the response of retinal vessel diameters to systemic glyceryl trinitrate (GTN) and stimulation with diffuse luminance flicker in patients with diabetes and healthy control subjects. METHODS: Twenty patients with type 1 diabetes mellitus featuring no or mild nonproliferative diabetic retinopathy and 20 healthy, age-matched subjects were included in this study. A vessel analyzer was used for measurement of diameters of retinal arteries and veins. The response of diameters was measured continuously during stimulation with flickering light, as well as immediately after sublingual application of 0.8 mg GTN. RESULTS: The response of retinal vessels to flickering light was significantly reduced in the patients with diabetes (arteries: 2.9% in diabetes versus 7.0% in control subjects, P < 0.002; veins: 4.6% in diabetes versus 6.8% in control subjects, P = 0.020). GTN-induced vasodilatation was not different between the patients with diabetes and the healthy control subjects (P >or= 0.70). CONCLUSIONS: The present study confirmed reduced response of retinal vessels to stimulation with flickering light in diabetes. The response of retinal vessels to a direct NO-donor, however, was maintained. This result indicates that abnormal flicker-induced vasodilatation in diabetes is not a consequence of generally reduced retinal vascular reactivity (ClinicalTrials.gov number, NCT00432029). |
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Authors:
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Berthold Pemp; Gerhard Garhofer; Günther Weigert; Katharina Karl; Hemma Resch; Michael Wolzt; Leopold Schmetterer |
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Publication Detail:
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Type: Clinical Trial; Journal Article Date: 2009-04-15 |
Journal Detail:
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Title: Investigative ophthalmology & visual science Volume: 50 ISSN: 1552-5783 ISO Abbreviation: Invest. Ophthalmol. Vis. Sci. Publication Date: 2009 Sep |
Date Detail:
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Created Date: 2009-08-28 Completed Date: 2009-09-18 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7703701 Medline TA: Invest Ophthalmol Vis Sci Country: United States |
Other Details:
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Languages: eng Pagination: 4029-32 Citation Subset: IM |
Affiliation:
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Departments of Clinical Pharmacology and. |
| Data Bank Information | |
Bank Name/Acc. No.:
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ClinicalTrials.gov/NCT00432029 |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Blood Glucose / analysis Blood Pressure / physiology Diabetes Mellitus, Type 1 / physiopathology* Diabetic Retinopathy / physiopathology* Female Hemoglobin A, Glycosylated / analysis Humans Intraocular Pressure / physiology Male Nitric Oxide / pharmacology Nitroglycerin / pharmacology* Photic Stimulation* Retinal Vessels / physiopathology* Vasodilation / drug effects*, radiation effects* Vasodilator Agents / pharmacology Visual Acuity |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Hemoglobin A, Glycosylated; 0/Vasodilator Agents; 0/hemoglobin A1c protein, human; 10102-43-9/Nitric Oxide; 55-63-0/Nitroglycerin |
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