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Reduced retinal ganglion cell complex thickness in patients with posterior cerebral artery infarction detected using spectral-domain optical coherence tomography.
MedLine Citation:
PMID:  22684619     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
PURPOSE: To report a reduction in macular ganglion cell complex (GCC) thickness detected with spectral-domain optical coherence tomography (SD-OCT) in patients with homonymous hemianopia following acquired cerebral damage. METHODS: We analyzed case reports of three patients with unilateral posterior cerebral artery (PCA) infarction. Three patients (aged 66, 68, and 71 years) with left homonymous hemianopia due to infarction of the right PCA territory were studied using SD-OCT. The duration of the lesions from the onset ranged from 12 to 36 months. RESULTS: In all of these patients, although optic atrophy and retinal nerve fiber layer defects were not detected on funduscopy, GCC thinning was demonstrated in the hemiretinae corresponding to the affected hemifields. Macular GCC measurements showed the localized defects of retinal ganglion cells (RGCs) more clearly than circumpapillary retinal nerve fiber layer measurements. Total and outer retinal thicknesses were not found to be significantly affected. CONCLUSION: Our findings suggest that degeneration of RGCs can occur within a few years after PCA infarction.
Authors:
Tsutomu Yamashita; Atsushi Miki; Yasuyuki Iguchi; Kazumi Kimura; Fumiatsu Maeda; Junichi Kiryu
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-6-9
Journal Detail:
Title:  Japanese journal of ophthalmology     Volume:  -     ISSN:  1613-2246     ISO Abbreviation:  -     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-6-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0044652     Medline TA:  Jpn J Ophthalmol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Sensory Science, Faculty of Health Science and Technology, Kawasaki University of Medical Welfare, 288 Matsushima, Kurashiki, Okayama, 701-0193, Japan.
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