| Reduced responses of macrophages on nanometer surface features of altered alumina crystalline phases. | |
| | |
MedLine Citation:
|
PMID: 19264563 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Extensive prolonged interactions of inflammatory cells (such as macrophages) at the host-implant interface may lead to implant failure. While previous studies have shown increased in vitro and in vivo bone cell adhesion, proliferation and mineralization on nanophase compared to currently implanted ceramics, few studies have been conducted to elucidate inflammatory cell responses on such nanophase ceramics. Controlling surface feature size and corresponding surface roughness on implants may clearly alter immune cell responses, which would be an extremely important consideration for the use of nanostructured materials as improved biomaterials. In this study, reduced macrophage density was observed on alumina (Al(2)O(3)) compacts with greater nanometer surface roughness accompanied by changes in crystallinity for up to 24 h in culture. Since alumina is a commonly used ceramic in orthopedic applications, this in vitro study continues to support the use of nanophase ceramics as improved orthopedic implants by demonstrating reduced macrophage responses. |
| | |
Authors:
|
Dongwoo Khang; Peishan Liu-Snyder; Rajesh Pareta; Jing Lu; Thomas J Webster |
Related Documents
:
|
9029293 - Fatigue behavior of zirconia hip joint heads: experimental results and finite element a... 15948443 - Alternative bearing surfaces: alumina ceramic bearings for total hip arthroplasty. 18672003 - Neurotrophic electrode: method of assembly and implantation into human motor speech cor... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-02-01 |
Journal Detail:
|
Title: Acta biomaterialia Volume: 5 ISSN: 1878-7568 ISO Abbreviation: - Publication Date: 2009 Jun |
Date Detail:
|
Created Date: 2009-05-05 Completed Date: 2009-07-16 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101233144 Medline TA: Acta Biomater Country: England |
Other Details:
|
Languages: eng Pagination: 1425-32 Citation Subset: IM |
Affiliation:
|
Division of Engineering and Department of Orthopaedics, Brown University, Providence, RI 02818, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aluminum Oxide
/
chemistry* Cell Adhesion / drug effects Cell Count Cell Line Cell Shape / drug effects Crystallization Hydrogen-Ion Concentration / drug effects Lipopolysaccharides / pharmacology Macrophages / cytology*, drug effects Nanoparticles / chemistry*, ultrastructure Particle Size* Surface Properties / drug effects X-Ray Diffraction |
| Chemical | |
Reg. No./Substance:
|
0/Lipopolysaccharides; 1344-28-1/Aluminum Oxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Direct analysis of valsartan or candesartan in human plasma and urines by on-line solid phase extrac...
Next Document: Micromechanical properties of single crystal hydroxyapatite by nanoindentation.