Document Detail

Reduced renal function is associated with combined increases in ventricular-systolic stiffness and arterial load in patients undergoing cardiac catheterization for coronary artery disease.
MedLine Citation:
PMID:  20953615     Owner:  NLM     Status:  In-Data-Review    
Although mildly reduced renal function is associated with increased risk for heart failure in patients with coronary artery disease (CAD), mechanisms underlying the association remain unclear. We tested the hypothesis that abnormal ventricular-arterial interaction may occur in mildly reduced renal function. We examined the relationships of the estimated glomerular filtration rate (eGFR) with various indices reflecting ventricular-arterial coupling [effective arterial elastance (the ratio of left ventricular (LV) end-systolic pressure to stroke volume, E (a)], LV end-systolic elastance (the ratio of LV end-systolic pressure to end-systolic volume, E (es)), and the total arterial compliance (the ratio of stroke volume to aortic pulse pressure)] and those of LV systolic and diastolic function [peak systolic and diastolic mitral annular velocities (S' and E') and the ratio of peak early diastolic mitral inflow to annular velocity (E/E')] in 320 consecutive patients who underwent cardiac catheterization for CAD and had normal (≥0.50) ejection fractions (EF). As eGFR decreased, E (a) and E (es) increased and total arterial compliance and E' decreased. eGFR did not correlate with E (a)/E (es), S', or E/E'. After adjusting for potential confounders, the findings were generally similar, but the correlation of eGFR with E' did not remain significant. In conclusion, reduced renal function may be associated with combined increases in ventricular-systolic stiffness and arterial load in known or suspected CAD patients with normal EF.
Hidekatsu Fukuta; Nobuyuki Ohte; Kazuaki Wakami; Kaoru Asada; Toshihiko Goto; Seiji Mukai; Genjiro Kimura
Related Documents :
668085 - Models of congenital heart disease in fetal lambs.
7087515 - The absence of temperature effects on end-diastolic pressure-volume relations in the ca...
25208015 - Errors in measurements of 222rn in methane and carbon dioxide using scintillation cells...
19124935 - Lv based pacing in patients with heart failure and a narrow qrs--an acute hemodynamic s...
11814105 - Mini hemoreliable axial flow lvad with magnetic bearings: part 1: historical overview a...
8337855 - Implications of an audible third heart sound in evaluating cardiac function.
Publication Detail:
Type:  Journal Article     Date:  2010-10-16
Journal Detail:
Title:  Heart and vessels     Volume:  26     ISSN:  1615-2573     ISO Abbreviation:  Heart Vessels     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-03-03     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8511258     Medline TA:  Heart Vessels     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  10-6     Citation Subset:  IM    
Department of Cardio-Renal Medicine and Hypertension, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, 467-8601, Japan,
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Are pulmonary artery pulsatility indexes able to differentiate chronic pulmonary thromboembolism fro...
Next Document:  Coffee consumption but not green tea consumption is associated with adiponectin levels in Japanese m...