Document Detail

Reduced reciprocal inhibition is seen only in spastic limbs in patients with neurolathyrism.
MedLine Citation:
PMID:  17571255     Owner:  NLM     Status:  MEDLINE    
If reduced reciprocal inhibition plays a causal role in the pathophysiology of spasticity as has been suggested in several studies, the inhibition is expected to be impaired in spastic, but not in normal muscles. Patients with neurolathyrism offer a possibility of testing this prediction since the spastic symptoms in these patients are restricted to the lower extremities only. Three patients with neurolathyrism were tested. Their data were compared with 15 age-matched healthy subjects. All patients showed signs of spasticity in the legs. Two patients had normal voluntary muscle force in the lower extremities and one had decreased force. No clinical abnormalities were found in the upper extremities. Reciprocal inhibition between ankle dorsiflexor and plantarflexor muscles was absent in all patients, whereas the inhibition between wrist extensor and flexor muscles was present and of normal size and latency. These findings are consistent with the hypothesis that reduced reciprocal inhibition plays a causal role in the pathophysiology of spasticity.
C Crone; N T Petersen; S Gimenéz-Roldán; B Lungholt; K Nyborg; J B Nielsen
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Publication Detail:
Type:  Journal Article     Date:  2007-06-15
Journal Detail:
Title:  Experimental brain research     Volume:  181     ISSN:  1432-1106     ISO Abbreviation:  Exp Brain Res     Publication Date:  2007 Jul 
Date Detail:
Created Date:  2007-07-02     Completed Date:  2008-05-15     Revised Date:  2013-12-13    
Medline Journal Info:
Nlm Unique ID:  0043312     Medline TA:  Exp Brain Res     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  193-7     Citation Subset:  IM    
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MeSH Terms
Electric Stimulation / methods
Electromyography / methods
Evoked Potentials, Motor / physiology,  radiation effects
Lathyrism / complications,  pathology*
Muscle Spasticity / physiopathology*
Neural Inhibition / physiology*
Peroneal Nerve / physiopathology,  radiation effects
Radial Nerve / physiopathology,  radiation effects
Reaction Time / physiology,  radiation effects
Transcranial Magnetic Stimulation / methods

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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