| Reduced rate of alveolar-capillary recruitment and fall of pulmonary diffusing capacity during exercise in patients with heart failure. | |
| | |
MedLine Citation:
|
PMID: 16679264 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Patients with chronic heart failure (CHF) have reduced pulmonary diffusing capacity for carbon monoxide (DLCO). Acute pulmonary congestion also causes reduction of DLCO, which is reversible. We hypothesized for patients with CHF that the rate of rise of exercise DLCO is reduced compared to healthy controls and falls near end-exercise consistent with progressive interstitial edema. METHODS AND RESULTS: DLCO and pulmonary blood flow (QC)) were measured by a rebreathe technique in CHF subjects (n = 11) and controls (n = 8) at rest, during constant workload exercise, and after exercise. DLCO of CHF subjects was less than controls at rest (16.5 +/- 1 vs. 21.9 +/- 2 mL/min/mm Hg, P < .01). CHF subjects exercised 11 +/- 2 minutes to 90% peak VO2, whereas controls exercised 17 +/- 2 minutes, reaching 88% peak VO2. In CHF subjects, DLCO increased to 19 +/- 2 mL/min/mm Hg and for controls to 38 +/- 3 mL/min/mm Hg. During the final 3 minutes of exercise, DLCO increased 5% in controls while decreasing 5% in CHF subjects (DLCO/Q(C)) was lower in CHF subjects at rest and progressively lower throughout exercise (P < .01). CONCLUSION: In patients with CHF, DLCO has reduced rate of rise with exercise and falls near end-exercise consistent with limitation of alveolar-capillary recruitment and progressive interstitial edema. |
| | |
Authors:
|
Lyle J Olson; Eric M Snyder; Kenneth C Beck; Bruce D Johnson |
Related Documents
:
|
12445534 - Combined endurance/resistance training reduces plasma tnf-alpha receptor levels in pati... 19398374 - A longitudinal study of quality of life in patients with chronic heart failure followin... 17301634 - The effect of endurance training on exercise capacity following cardiac resynchronizati... 20663654 - Effects of interval exercise training on respiratory drive in patients with chronic hea... 12391094 - Concentric adaptation of the left ventricle in response to controlled upper body exerci... 18201114 - Head and neck position sense. |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Journal of cardiac failure Volume: 12 ISSN: 1532-8414 ISO Abbreviation: J. Card. Fail. Publication Date: 2006 May |
Date Detail:
|
Created Date: 2006-05-08 Completed Date: 2006-09-19 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 9442138 Medline TA: J Card Fail Country: United States |
Other Details:
|
Languages: eng Pagination: 299-306 Citation Subset: IM |
Affiliation:
|
Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Breath Tests Capillaries / physiopathology Carbon Dioxide / analysis Exercise / physiology* Female Heart Failure / physiopathology* Humans Lung / blood supply* Male Middle Aged Oxygen Consumption Pulmonary Alveoli / physiopathology* Pulmonary Diffusing Capacity* / physiology Pulmonary Gas Exchange Regional Blood Flow |
| Grant Support | |
ID/Acronym/Agency:
|
M01-RR00585/RR/NCRR NIH HHS; R01-HL71478/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
|
124-38-9/Carbon Dioxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Myocarditis and heart failure associated with hepatitis C virus infection.
Next Document: The symptom of pain with heart failure: a systematic review.