Document Detail

Reduced pulmonary surfactant interaction of daptomycin analogs via tryptophan replacement with alternative amino acids.
MedLine Citation:
PMID:  22951041     Owner:  NLM     Status:  Publisher    
Daptomycin was shown to interact in vitro with pulmonary surfactant leading to reduction of its antibacterial activity. We report herein the preparation and anti-staphylococcal activity of a series of daptomycin analogs with reduced pulmonary surfactant interaction by replacing tryptophan with various amino acids.
Yong He; Jing Li; Nin Yin; Prudencio S Herradura; Larry Martel; Yanzhi Zhang; Andre L Pearson; Vidya Kulkarni; Carmela Mascio; Karen Howland; Jared A Silverman; Dennis D Keith; Chester A Metcalf
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-9
Journal Detail:
Title:  Bioorganic & medicinal chemistry letters     Volume:  -     ISSN:  1464-3405     ISO Abbreviation:  Bioorg. Med. Chem. Lett.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-9-6     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9107377     Medline TA:  Bioorg Med Chem Lett     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
Cubist Pharmaceuticals, 65 Hyden Ave, Lexington, MA 02421, United States.
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