| Reduced pulmonary surfactant interaction of daptomycin analogs via tryptophan replacement with alternative amino acids. | |
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MedLine Citation:
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PMID: 22951041 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Daptomycin was shown to interact in vitro with pulmonary surfactant leading to reduction of its antibacterial activity. We report herein the preparation and anti-staphylococcal activity of a series of daptomycin analogs with reduced pulmonary surfactant interaction by replacing tryptophan with various amino acids. |
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Authors:
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Yong He; Jing Li; Nin Yin; Prudencio S Herradura; Larry Martel; Yanzhi Zhang; Andre L Pearson; Vidya Kulkarni; Carmela Mascio; Karen Howland; Jared A Silverman; Dennis D Keith; Chester A Metcalf |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-8-9 |
Journal Detail:
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Title: Bioorganic & medicinal chemistry letters Volume: - ISSN: 1464-3405 ISO Abbreviation: Bioorg. Med. Chem. Lett. Publication Date: 2012 Aug |
Date Detail:
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Created Date: 2012-9-6 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9107377 Medline TA: Bioorg Med Chem Lett Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012 Elsevier Ltd. All rights reserved. |
Affiliation:
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Cubist Pharmaceuticals, 65 Hyden Ave, Lexington, MA 02421, United States. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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