Document Detail

Reduced pulmonary clearance of endothelin-1 in pulmonary hypertension.
MedLine Citation:
PMID:  9539476     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Pulmonary hypertension (PHT) is associated with increased endothelin-1 (ET-1) levels that correlate with the severity of the disease. The pulmonary circulation is an important site for ET-1 metabolism and may modulate plasma ET-1 through an increase in production, a reduction in removal, or a combination of both. We measured and compared pulmonary metabolism of circulating ET-1 in controls and in patients with PHT. METHODS AND RESULTS: The indicator-dilution technique was combined with measurements of ET-1 levels to quantify pulmonary metabolism of ET-1 in controls (n = 13) and in patients with PHT (n = 17). ET-1 levels doubled in PHT (p < 0.05) and, although there was no difference between aortic and pulmonary artery levels in controls (0.68+/-0.09 and 0.61+/-0.08 pg/ml, respectively, p = 0.22), they tended to be higher in PHT (1.23+/-0.26 vs 1.07+/-0.19 pg/ml, p = 0.08). Pulmonary extraction of tracer iodine-125-ET-1 was reduced from 47%+/-2.0% in the controls to 34%+/-3.6% in PHT (p = 0.005) and inversely correlated with the severity of pulmonary hypertension (r = -0.524, p = 0.03). Consequently, circulating ET-1 clearance was reduced by PHT from 1424+/-77 ml/min to 892+/-119 ml/min (p < 0.001). Pulmonary production of circulating ET-1 (in picograms per minute) was not different but the quantity of ET-1 that survives passage through the lungs was increased by PHT (1860+/-359 pg/min vs 992+/-152 pg/min, p = 0.037). CONCLUSION: PHT is associated with a reduced pulmonary clearance of ET-1 that contributes to the increase in circulating levels.
J Dupuis; P Cernacek; J C Tardif; D J Stewart; G Gosselin; I Dyrda; R Bonan; J Crépeau
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American heart journal     Volume:  135     ISSN:  0002-8703     ISO Abbreviation:  Am. Heart J.     Publication Date:  1998 Apr 
Date Detail:
Created Date:  1998-04-24     Completed Date:  1998-04-24     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370465     Medline TA:  Am Heart J     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  614-20     Citation Subset:  AIM; IM    
Department of Medicine, Montreal Heart Institute, Quebec, Canada.
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MeSH Terms
Aorta, Thoracic
Biological Markers / blood
Blood Pressure
Endothelin-1 / biosynthesis,  blood*
Heart Catheterization
Heart Failure / complications,  diagnosis
Hypertension, Pulmonary / blood*,  etiology,  ultrasonography
Iodine Radioisotopes / diagnostic use
Middle Aged
Mitral Valve Stenosis / complications,  diagnosis
Pulmonary Artery / metabolism
Pulmonary Wedge Pressure
Severity of Illness Index
Vascular Resistance
Reg. No./Substance:
0/Biological Markers; 0/Endothelin-1; 0/Iodine Radioisotopes

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