| Reduced prostaglandin F2 alpha release from blood mononuclear leukocytes after oral supplementation of omega3 fatty acids: the OmegAD study. | |
| | |
MedLine Citation:
|
PMID: 19965584 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Omega-3 fatty acids, e.g., dokosahexaenoic acid (DHA) and eikosapentaenoic acid (EPA), ameliorate inflammatory reactions by various mechanisms, but the role of prostaglandins remains unclear. Our aim was to determine if dietary supplementation with a DHA-rich fish oil influenced the release of PGF(2alpha) from peripheral blood mononuclear cells (PBMC). In the OmegAD study, 174 Alzheimer disease patients received either 1.7 g DHA plus 0.6 g EPA or a placebo daily for six months. PBMCs from the 21 (9 on fish oil and 12 on placebo) first-randomized patients were stimulated with either lipopolysaccharide (LPS) or phytohemagglutinin (PHA) before and after 6 months. Our results showed that plasma concentrations of DHA and EPA increased significantly at 6 months in the omega-3 group. PGF(2alpha) release from LPS- (but not from PHA-) stimulated PBMC was significantly diminished in this group; no change was noted in the placebo group. PGF(2alpha) changes correlated inversely with changes in plasma DHA and EPA. Decreased IL-6 and IL-1(beta) levels correlated with decreased PGF(2alpha) levels. The stimulus-specific PGF(2alpha) release from PBMC after 6 months of oral supplementation with the DHA-rich fish oil might be one event related to reduced inflammatory reactions associated with omega-3 fatty acid intake. |
| | |
Authors:
|
Inger Vedin; Tommy Cederholm; Yvonne Freund-Levi; Hans Basun; Erik Hjorth; Gerd Faxén Irving; Maria Eriksdotter-Jönhagen; Marianne Schultzberg; Lars-Olof Wahlund; Jan Palmblad |
Related Documents
:
|
18166254 - Essential versus potentially toxic dietary substances: a seasonal comparison of essenti... 9150374 - Cytotoxic action of alpha-linolenic and eicosapentaenoic acids on myeloma cells in vitro. 11201994 - Hepatic microsomal and peroxisomal docosahexaenoate biosynthesis during piglet developm... 15716794 - N-3 fatty acids and pregnancy outcomes. 2333334 - Quantitative conversion of the (6-4) photoproduct of tpdc to its dewar valence isomer u... 11942484 - Selective (r)-3-hydroxylation of fa by stenotrophomonas maltophilia. |
Publication Detail:
|
Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't Date: 2009-11-24 |
Journal Detail:
|
Title: Journal of lipid research Volume: 51 ISSN: 0022-2275 ISO Abbreviation: J. Lipid Res. Publication Date: 2010 May |
Date Detail:
|
Created Date: 2010-04-14 Completed Date: 2010-07-07 Revised Date: 2011-07-28 |
Medline Journal Info:
|
Nlm Unique ID: 0376606 Medline TA: J Lipid Res Country: United States |
Other Details:
|
Languages: eng Pagination: 1179-85 Citation Subset: IM |
Affiliation:
|
Department of Medicine, Caring Sciences and Society, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden. inger.vedin@ki.se |
| Data Bank Information | |
Bank Name/Acc. No.:
|
ClinicalTrials.gov/NCT00211159 |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Administration, Oral Aged Aged, 80 and over Alzheimer Disease / blood, metabolism Culture Media, Conditioned / metabolism Cytokines / metabolism Dietary Supplements* Dinoprost / biosynthesis, blood, metabolism* Fatty Acids, Omega-3 / administration & dosage*, blood, pharmacology* Female Humans Leukocytes, Mononuclear / drug effects*, metabolism* Lipopolysaccharides / pharmacology Male Middle Aged Monocytes / drug effects, metabolism Phytohemagglutinins / pharmacology T-Lymphocytes / drug effects, metabolism |
| Chemical | |
Reg. No./Substance:
|
0/Culture Media, Conditioned; 0/Cytokines; 0/Fatty Acids, Omega-3; 0/Lipopolysaccharides; 0/Phytohemagglutinins; 551-11-1/Dinoprost |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Identification of atypical ether-linked glycerophospholipid species in macrophages by mass spectrome...
Next Document: Cholesterol efflux to apoA-I in ABCA1-expressing cells is regulated by Ca2+-dependent calcineurin si...