Document Detail


Reduced progesterone metabolites in human late pregnancy.
MedLine Citation:
PMID:  21114373     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In this review, we focused on the intersection between steroid metabolomics, obstetrics and steroid neurophysiology to give a comprehensive insight into the role of sex hormones and neuroactive steroids (NAS) in the mechanism controlling pregnancy sustaining. The data in the literature including our studies show that there is a complex mechanism providing synthesis of either pregnancy sustaining or parturition provoking steroids. This mechanism includes the boosting placental synthesis of CRH with approaching parturition inducing the excessive synthesis of 3beta-hydroxy-5-ene steroid sulfates serving primarily as precursors for placental synthesis of progestogens, estrogens and NAS. The distribution and changing activities of placental oxidoreductases are responsible for the activation or inactivation of the aforementioned steroids, which is compartment-specific (maternal and fetal compartments) and dependent on gestational age, with a tendency to shift the production from the pregnancy-sustaining steroids to the parturition provoking ones with an increasing gestational age. The fetal and maternal livers catabolize part of the bioactive steroids and also convert some precursors to bioactive steroids. Besides the progesterone, a variety of its 5alpha/beta-reduced metabolites may significantly influence the maintenance of human pregnancy, provide protection against excitotoxicity following acute hypoxic stress, and might also affect the pain perception in mother and fetus.
Authors:
M Hill; A Pařízek; R Kancheva; J E Jirásek
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2010-11-29
Journal Detail:
Title:  Physiological research / Academia Scientiarum Bohemoslovaca     Volume:  60     ISSN:  1802-9973     ISO Abbreviation:  Physiol Res     Publication Date:  2011  
Date Detail:
Created Date:  2011-05-10     Completed Date:  2011-09-09     Revised Date:  2011-10-21    
Medline Journal Info:
Nlm Unique ID:  9112413     Medline TA:  Physiol Res     Country:  Czech Republic    
Other Details:
Languages:  eng     Pagination:  225-41     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynecology of the First Faculty of Medicine and General Teaching Hospital, Prague, Czech Republic. parizek@porodnice.cz
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MeSH Terms
Descriptor/Qualifier:
Corticotropin-Releasing Hormone / biosynthesis
Estrogens / biosynthesis
Female
Fetus / metabolism
Humans
Liver / metabolism
Neurotransmitter Agents / biosynthesis
Oxidoreductases / metabolism
Pain Perception
Placenta / metabolism
Pregnancy / blood,  metabolism*
Pregnancy Trimester, Third / metabolism
Progesterone / blood,  metabolism*
Chemical
Reg. No./Substance:
0/Estrogens; 0/Neurotransmitter Agents; 57-83-0/Progesterone; 9015-71-8/Corticotropin-Releasing Hormone; EC 1.-/Oxidoreductases

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