Document Detail

Reduced production of interferon alpha and interferon gamma in leukocyte cultures from patients with active rheumatoid arthritis.
MedLine Citation:
PMID:  3114875     Owner:  NLM     Status:  MEDLINE    
Tests for lymphoproliferation and interferon induction in normal blood donors and patients with rheumatoid arthritis (RA) were performed in a whole-blood assay. Patients with high inflammatory RA showed significantly reduced lymphoproliferation and interferon gamma production after stimulation with phytohemagglutinin (PHA) and concanavalin A (Con A) when compared with patients with low inflammatory activity, or with normal control individuals. Similarly, patients with high and low inflammatory RA exhibited a significantly reduced interferon alpha production after stimulation with Newcastle Disease Virus (NDV) when compared with normal blood donors. Our findings may point to an important immunodeficiency of the circulating lymphocytes of RA patients and may explain some of the in vitro immunoregulatory abnormalities reported in this disease.
M Seitz; I Napierski; R Augustin; W Hunstein; H Kirchner
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Scandinavian journal of rheumatology     Volume:  16     ISSN:  0300-9742     ISO Abbreviation:  Scand. J. Rheumatol.     Publication Date:  1987  
Date Detail:
Created Date:  1987-10-19     Completed Date:  1987-10-19     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0321213     Medline TA:  Scand J Rheumatol     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  257-62     Citation Subset:  IM; X    
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MeSH Terms
Arthritis, Rheumatoid / blood*,  immunology
Cells, Cultured
Concanavalin A / pharmacology
Interferon Type I / biosynthesis*
Interferon-gamma / biosynthesis*
Leukocyte Count
Leukocytes / metabolism*
Lymphocyte Activation / drug effects
Phytohemagglutinins / pharmacology
Pokeweed Mitogens / pharmacology
Reg. No./Substance:
0/Interferon Type I; 0/Phytohemagglutinins; 0/Pokeweed Mitogens; 11028-71-0/Concanavalin A; 82115-62-6/Interferon-gamma

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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