Document Detail


Reduced plasma oestrogen stimulated neurophysin and delayed response to oestrogen challenge in Alzheimer's disease.
MedLine Citation:
PMID:  2284385     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Plasma concentrations of oestrogen stimulated neurophysin (ESN) were reduced in 28 patients with Alzheimer's disease (AD) compared with 14 age-matched controls, 16 patients with other presenile dementias and 12 patients with major depressive disorder. The ESN response to oestrogen challenge was delayed in 10 AD patients compared with 7 age-matched controls. Reduced basal and oestrogen stimulated plasma ESN may be related to impaired responsiveness of the hypothalamo-neurohypophysial neurons and/or a reduction in the amount of pituitary ESN available for release. Plasma ESN measurements may be of value for excluding the diagnosis of AD in patients with dementia who present before the age of 65.
Authors:
J Christie; R Hunter; J Bennie; H Wilson; S Carroll; G Fink
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Psychological medicine     Volume:  20     ISSN:  0033-2917     ISO Abbreviation:  Psychol Med     Publication Date:  1990 Nov 
Date Detail:
Created Date:  1991-03-15     Completed Date:  1991-03-15     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  1254142     Medline TA:  Psychol Med     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  773-7     Citation Subset:  IM    
Affiliation:
MRC Brain Metabolism Unit, Royal Edinburgh Hospital.
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Aged
Alzheimer Disease / blood,  diagnosis*,  psychology
Biological Markers / blood*
Dementia / blood,  diagnosis,  psychology
Depressive Disorder / blood,  diagnosis,  psychology
Estrogens / blood
Humans
Mestranol / diagnostic use*
Neurophysins / blood*
Radioimmunoassay
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Estrogens; 0/Neurophysins; 72-33-3/Mestranol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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