Document Detail

Reduced plasma nonesterified fatty acid levels and the advent of an acute lung injury in mice after intravenous or enteral oleic acid administration.
MedLine Citation:
PMID:  22529526     Owner:  NLM     Status:  MEDLINE    
Although exerting valuable functions in living organisms, nonesterified fatty acids (NEFAs) can be toxic to cells. Increased blood concentration of oleic acid (OLA) and other fatty acids is detected in many pathological conditions. In sepsis and leptospirosis, high plasma levels of NEFA and low albumin concentrations are correlated to the disease severity. Surprisingly, 24 h after intravenous or intragastric administration of OLA, main NEFA levels (OLA inclusive) were dose dependently decreased. However, lung injury was detected in intravenously treated mice, and highest dose killed all mice. When administered by the enteral route, OLA was not toxic in any tested conditions. Results indicate that OLA has important regulatory properties on fatty acid metabolism, possibly lowering circulating fatty acid through activation of peroxisome proliferator-activated receptors. The significant reduction in blood NEFA levels detected after OLA enteral administration can contribute to the already known health benefits brought about by unsaturated-fatty-acid-enriched diets.
Cassiano Felippe Gonçalves de Albuquerque; Patrícia Burth; Mauricio Younes Ibrahim; Diogo Gomes Garcia; Patrícia Torres Bozza; Hugo Caire Castro Faria Neto; Mauro Velho Castro Faria
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-02-27
Journal Detail:
Title:  Mediators of inflammation     Volume:  2012     ISSN:  1466-1861     ISO Abbreviation:  Mediators Inflamm.     Publication Date:  2012  
Date Detail:
Created Date:  2012-04-24     Completed Date:  2012-09-20     Revised Date:  2013-06-25    
Medline Journal Info:
Nlm Unique ID:  9209001     Medline TA:  Mediators Inflamm     Country:  United States    
Other Details:
Languages:  eng     Pagination:  601032     Citation Subset:  IM    
Laboratório de Imunofarmacologia, Fundação Oswaldo Cruz, FIOCRUZ, Rio de Janeiro 21040-900, Brazil.
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MeSH Terms
Acute Lung Injury / metabolism*
Albumins / metabolism
Bronchoalveolar Lavage Fluid
Dinoprostone / metabolism
Dose-Response Relationship, Drug
Fatty Acids / metabolism
Fatty Acids, Nonesterified / administration & dosage*,  metabolism*
Fatty Acids, Unsaturated / metabolism
Infusions, Intravenous
Leukotriene B4 / metabolism
Lipids / chemistry
Oleic Acid / administration & dosage*,  metabolism
Peroxisome Proliferator-Activated Receptors / metabolism
Stomach / metabolism
Reg. No./Substance:
0/Albumins; 0/Fatty Acids; 0/Fatty Acids, Nonesterified; 0/Fatty Acids, Unsaturated; 0/Lipids; 0/Peroxisome Proliferator-Activated Receptors; 112-80-1/Oleic Acid; 363-24-6/Dinoprostone; 71160-24-2/Leukotriene B4

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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