| Reduced plasma concentrations of nitrogen oxide in individuals with essential hypertension. | |
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MedLine Citation:
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PMID: 9314424 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Patients with essential hypertension exhibit blunted endothelium-dependent vasodilator responses, which may be largely attributable to reduced bioactivity of nitric oxide (NO). Therefore, we measured the end product of NO, nitrate plus nitrite (nitrogen oxide), and examined the relationship between the degree of hypertension and plasma nitrate plus nitrite levels in patients with essential hypertension. The combined plasma concentration of nitrate plus nitrite, end products of NO metabolism, was reduced in individuals with essential hypertension relative to that in control subjects (15.7+/-1.1 versus 22.8+/-1.4 mmol x L(-1), P<.001); individuals with borderline hypertension showed values that were intermediate between those of the other two groups (18.2+/-1.2 mmol x L(-1), P<.001). The plasma nitrogen oxide concentration showed significant inverse correlations with both systolic and diastolic blood pressures. The basal concentration of nitrogen oxide in the plasma was reduced, at least in the peripheral circulation, in individuals with essential hypertension. |
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Authors:
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K Node; M Kitakaze; H Yoshikawa; H Kosaka; M Hori |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Hypertension Volume: 30 ISSN: 0194-911X ISO Abbreviation: Hypertension Publication Date: 1997 Sep |
Date Detail:
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Created Date: 1997-10-30 Completed Date: 1997-10-30 Revised Date: 2006-12-27 |
Medline Journal Info:
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Nlm Unique ID: 7906255 Medline TA: Hypertension Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 405-8 Citation Subset: IM |
Affiliation:
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First Department of Medicine, Osaka University School of Medicine, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Female Humans Hypertension / blood* Male Middle Aged Nitrates / blood* Nitrites / blood* Osmolar Concentration Reference Values |
| Chemical | |
Reg. No./Substance:
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0/Nitrates; 0/Nitrites |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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