Document Detail

Reduced plasma concentrations of nitrogen oxide in individuals with essential hypertension.
MedLine Citation:
PMID:  9314424     Owner:  NLM     Status:  MEDLINE    
Patients with essential hypertension exhibit blunted endothelium-dependent vasodilator responses, which may be largely attributable to reduced bioactivity of nitric oxide (NO). Therefore, we measured the end product of NO, nitrate plus nitrite (nitrogen oxide), and examined the relationship between the degree of hypertension and plasma nitrate plus nitrite levels in patients with essential hypertension. The combined plasma concentration of nitrate plus nitrite, end products of NO metabolism, was reduced in individuals with essential hypertension relative to that in control subjects (15.7+/-1.1 versus 22.8+/-1.4 mmol x L(-1), P<.001); individuals with borderline hypertension showed values that were intermediate between those of the other two groups (18.2+/-1.2 mmol x L(-1), P<.001). The plasma nitrogen oxide concentration showed significant inverse correlations with both systolic and diastolic blood pressures. The basal concentration of nitrogen oxide in the plasma was reduced, at least in the peripheral circulation, in individuals with essential hypertension.
K Node; M Kitakaze; H Yoshikawa; H Kosaka; M Hori
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Hypertension     Volume:  30     ISSN:  0194-911X     ISO Abbreviation:  Hypertension     Publication Date:  1997 Sep 
Date Detail:
Created Date:  1997-10-30     Completed Date:  1997-10-30     Revised Date:  2006-12-27    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  405-8     Citation Subset:  IM    
First Department of Medicine, Osaka University School of Medicine, Japan.
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MeSH Terms
Hypertension / blood*
Middle Aged
Nitrates / blood*
Nitrites / blood*
Osmolar Concentration
Reference Values
Reg. No./Substance:
0/Nitrates; 0/Nitrites

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