Document Detail

Reduced plasma antioxidants in first-episode patients with schizophrenia.
MedLine Citation:
PMID:  12837516     Owner:  NLM     Status:  MEDLINE    
Recent findings suggest that free radical-mediated pathological processes may underlie membrane deficits that have been observed in schizophrenia. We have previously demonstrated that both total antioxidant status (TAS) and individual antioxidants were significantly reduced in plasma of chronic schizophrenic patients, on and off haloperidol. To test whether reductions in plasma antioxidants are independent of treatment or illness progression, levels of plasma antioxidants were evaluated in 43 patients at first-episode of psychosis, 31 patients meeting DSM-IV criteria for schizophrenia or schizoaffective disorder (reconfirmed after 6 months) and 12 patients with primary mood (bipolar or depressive (BP/D)) disorder, at neuroleptic-naive baseline as well as 40 age- and sex-matched normal controls (NC). The major plasma antioxidants albumin, uric acid and bilirubin were all significantly lower in the first-episode schizophrenic, but not in the BP/D patients, than in normal controls. Factors that can affect these antioxidants-age, gender, diet and smoking-were examined. Body mass index (BMI) was significantly lower in patients, but was not correlated with plasma albumin and bilirubin; there was a trend for a correlation with uric acid in schizophrenic patients. Lower antioxidant levels were independent of smoking status of patients. The present data suggest that a defect in the antioxidant defense system (AODS), which may lead to oxidative damage, occurs early in the course of illness and is independent of treatment effects.
Ravinder Reddy; Matcheri Keshavan; Jeffrey K Yao
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Schizophrenia research     Volume:  62     ISSN:  0920-9964     ISO Abbreviation:  Schizophr. Res.     Publication Date:  2003 Aug 
Date Detail:
Created Date:  2003-07-02     Completed Date:  2003-12-01     Revised Date:  2010-09-02    
Medline Journal Info:
Nlm Unique ID:  8804207     Medline TA:  Schizophr Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  205-12     Citation Subset:  IM    
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, 3811 O'Hara Street, Pittsburgh, PA 15213, USA.
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MeSH Terms
Albumins / analysis
Antioxidants / metabolism*
Bilirubin / analysis
Cell Membrane
Chronic Disease
Diagnostic and Statistical Manual of Mental Disorders
Erythrocytes / cytology
Schizophrenia / blood*,  diagnosis,  drug therapy*
Severity of Illness Index
Uric Acid / blood
Grant Support
Reg. No./Substance:
0/Albumins; 0/Antioxidants; 635-65-4/Bilirubin; 69-93-2/Uric Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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