Document Detail

Reduced placental perfusion causes an increase in maternal serum leptin.
MedLine Citation:
PMID:  13129685     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: We tested the hypothesis that the inadequately perfused placenta increases production of leptin, which can be detected in maternal serum. STUDY DESIGN: Sprague-Dawley rats (n=13), on day 14 of gestation, had placement of clips on the aorta and the ovarian arteries providing 35 per cent occlusion of the vessels. Eight rats had sham surgery and 14 rats served as non-surgical controls. All animals were sacrificed on day 19 of gestation. Maternal serum was obtained, and pups and placentae were weighed. RESULTS: Both placental weights and pup weights were reduced due to reduced uterine perfusion and were negatively correlated with maternal serum leptin (P=0.018 and 0.028, respectively). Maternal serum leptin was increased in the treatment group (2.21 ng/ml+/-64 ng/ml) compared to controls (1.66 ng/ml+/-38 ng/ml) (P=0.031). CONCLUSIONS: Our findings suggest that reduced placental perfusion results in an increase in maternal serum leptin. Further investigation is needed to determine if maternal serum leptin may be useful in identifying pregnancies with uteroplacental insufficiency.
L E Moore; K L Wallace; B T Alexander; W L May; B D Thigpen; W A Bennett
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Placenta     Volume:  24     ISSN:  0143-4004     ISO Abbreviation:  Placenta     Publication Date:    2003 Sep-Oct
Date Detail:
Created Date:  2003-09-17     Completed Date:  2004-05-13     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8006349     Medline TA:  Placenta     Country:  England    
Other Details:
Languages:  eng     Pagination:  877-81     Citation Subset:  IM    
Department of Obstetrics and Gynecology, University of Mississippi Medical Center, Jackson, MS 39216-4505, USA.
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MeSH Terms
Animals, Newborn
Body Weight
Embryonic and Fetal Development / physiology
Gestational Age
Leptin / biosynthesis,  blood*
Ligation / methods
Litter Size
Maternal-Fetal Exchange
Models, Animal
Organ Size
Placenta / blood supply*,  physiology*
Pregnancy / blood*
Rats, Sprague-Dawley
Reg. No./Substance:

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