Document Detail


Reduced occurrence of early atopic dermatitis because of immunoactive prebiotics among low-atopy-risk infants.
MedLine Citation:
PMID:  20832848     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Most infants developing atopic dermatitis have a low risk for atopy. Primary prevention of atopic dermatitis is difficult.
OBJECTIVE: To assess the effect of supplementation of an infant and follow-on formula with prebiotic and immunoactive oligosaccharides on the occurrence of atopic dermatitis in the first year of life.
METHODS: Healthy term infants from 5 European countries with low atopy risk were recruited before the age of 8 weeks, either having started with formula feeding or being on full breast-feeding (breast-feeding group). Formula-fed infants were randomized to feeding with a regular formula containing a specific mixture of neutral oligosaccharides and pectin-derived acidic oligosaccharides (prebiotic formula group) or regular formula without oligosaccharides (control formula group).
RESULTS: A total of 414 infants were randomized to the prebiotic group and 416 infants to the control group. A total of 300 infants were followed in the breast-feeding group. Up to the first birthday, atopic dermatitis occurred in significantly fewer infants from the prebiotic group (5.7%) than from the control group (9.7%; P = .04). The cumulative incidence of atopic dermatitis in the prebiotic group was in the low range of the breast-feeding group (7.3%). In a Cox regression model, the rate of atopic dermatitis was significantly lower by 44% in the prebiotic group versus the control group (P = .04). The number needed to prevent 1 case of atopic dermatitis by supplementation of prebiotics was 25 infants.
CONCLUSION: Formula supplementation with a specific mixture of oligosaccharides was effective as primary prevention of atopic dermatitis in low atopy risk infants.
Authors:
Christoph Grüber; Margriet van Stuijvenberg; Fabio Mosca; Guido Moro; Gaetano Chirico; Christian P Braegger; Josef Riedler; Günther Boehm; Ulrich Wahn;
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2010-09-15
Journal Detail:
Title:  The Journal of allergy and clinical immunology     Volume:  126     ISSN:  1097-6825     ISO Abbreviation:  J. Allergy Clin. Immunol.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-10-05     Completed Date:  2010-11-12     Revised Date:  2010-12-27    
Medline Journal Info:
Nlm Unique ID:  1275002     Medline TA:  J Allergy Clin Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  791-7     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2010 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.
Affiliation:
Department of Pediatric Pneumology and Immunology, Charité-Universitätsmedizin Berlin, Berlin, Germany. christoph.grueber@charite.de
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MeSH Terms
Descriptor/Qualifier:
Breast Feeding
Dermatitis, Atopic / epidemiology,  immunology,  prevention & control*
Dietary Supplements
Double-Blind Method
Europe
Female
Humans
Incidence
Infant
Infant Formula
Infant, Newborn
Male
Oligosaccharides / administration & dosage*
Prebiotics*
Primary Prevention / methods
Prospective Studies
Treatment Outcome
Chemical
Reg. No./Substance:
0/Oligosaccharides; 0/Prebiotics
Investigator
Investigator/Affiliation:
Pieter Sauer / ; Margriet van Stuijvenberg / ; Annemieke Eisses / ; Jitty Streurman / ; Ulrich Wahn / ; Christoph Grüber / ; Juliane Wauer / ; Kirn Parasher / ; Madeleine Wust / ; Ingrid Lawnitzak / ; Marion Trentmann / ; Gabi Schulz / ; Eckard Hamelmann / ; Paola Roggero / ; Pasquina Piemontese / ; Anna Orsi / ; Valeria Puricelli / ; Fabio Mosca / ; Sertac Arslanoglu / ; Guido Moro / ; Silvia Rizzardi / ; Michela Coppola / ; Elisa Rigotti / ; Laura Tandoi / ; Christian Braegger / ; Michael Friedt / ; Rebecca Koller / ; Petra Martel / ; Sarah Nussbaumer / ; Daniela Rogler / ; Tamar Stricker / ; Josef Riedler / ; Margret Macheiner / ; Christine Tyma / ; Gaetano Chirico / ; Antonella Gasparoni / ; Elena Garzoli / ; Chiara Offer / ; Vania Spinoni / ; Graziella Iacono / ; Maria Stellini / ; Jürgen Jelinek / ; Bernd Stahl / ; Esther König / ; Anja Frings / ; Yvonne Zens / ; Anja Wittke / ; Stephanie Cremers / ; Janina Gerloff / ; Kathrin Friedrichs / ; Ayako Fischer / ; Gemma Bruno / ; Günther Boehm / ; Jan van der Mooren / ; Johan Garssen / ; Leon Knippels / ; Chryssanthi Kiriakidou / ; Joop Pfeil /

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