Document Detail

Reduced number of intrinsic pulmonary nitrergic neurons in Fawn-Hooded rats as compared to control rat strains.
MedLine Citation:
PMID:  12704702     Owner:  NLM     Status:  MEDLINE    
The Fawn-Hooded rat (FHR) strain reveals a congenital predisposition to primary (idiopathic) pulmonary hypertension (PPH), and can therefore be regarded as an animal model in which to study possible mechanisms underlying an inherited susceptibility to pulmonary hypertension. Pulmonary hypertension can be induced in FHRs after a short exposure to mild hypoxia, presumably because of an altered peripheral oxygen sensitivity. Given the presence of pulmonary nitrergic neurons in rat lungs, the observed link between airway hypoxia and the expression of pulmonary neuronal nitric oxide synthase (nNOS), and the fact that nNOS appears to be involved in peripheral chemoreceptor sensitivity, we examined the intrinsic pulmonary nitrergic innervation in the FHR. In the present study the number of intrapulmonary nitrergic nerve cell bodies, detected by NADPH diaphorase (NADPHd) histochemistry, was quantified in the FHR and three control rat strains. Compared to the control rat strains, the FHR lungs revealed a highly significantly lower number of intrinsic nitrergic neurons, while no apparent differences were found in the number of enteric nitrergic neurons in the esophagus. In conclusion, the possible links between neuronal NO, hypersensitivity to airway hypoxia, and the development of PPH clearly deserve further investigation.
Jeroen Van Genechten; Inge Brouns; Dietrich W Scheuermann; Jean-Pierre Timmermans; Dirk Adriaensen
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology     Volume:  272     ISSN:  1552-4884     ISO Abbreviation:  -     Publication Date:  2003 May 
Date Detail:
Created Date:  2003-04-21     Completed Date:  2004-01-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  101234285     Medline TA:  Anat Rec A Discov Mol Cell Evol Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  446-53     Citation Subset:  IM    
Copyright Information:
Copyright 2003 Wiley-Liss, Inc.
Laboratory of Cell Biology and Histology, Department of Biomedical Sciences, University of Antwerp (RUCA), Antwerp, Belgium.
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MeSH Terms
Autonomic Pathways / abnormalities*,  enzymology,  pathology
Cell Count
Disease Models, Animal
Down-Regulation / physiology
Genetic Predisposition to Disease / genetics
Hypertension, Pulmonary / genetics,  pathology*,  physiopathology
NADPH Dehydrogenase / metabolism
Nitrergic Neurons / enzymology,  pathology*
Nitric Oxide / metabolism
Nitric Oxide Synthase / metabolism
Pulmonary Artery / abnormalities*,  innervation,  pathology
Rats, Inbred F344
Rats, Mutant Strains / abnormalities*
Rats, Sprague-Dawley
Rats, Wistar
Species Specificity
Vasoconstriction / physiology
Reg. No./Substance:
10102-43-9/Nitric Oxide; EC Oxide Synthase; EC Dehydrogenase

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