Document Detail

Reduced nitric oxide in the rostral ventrolateral medulla enhances cardiac sympathetic afferent reflex in rats with chronic heart failure.
MedLine Citation:
PMID:  14985829     Owner:  NLM     Status:  MEDLINE    
The purpose of this study was to determine the effect of nitric oxide (NO) in the rostral ventrolateral medulla (RVLM) on the central integration of the cardiac sympathetic afferent reflex (CSAR) in normal rats and in rats with coronary ligation-induced chronic heart failure (CHF). Under alpha-chloralose and urethane anesthesia, mean arterial pressure, heart rate and renal sympathetic nerve activity (RSNA) were recorded at baseline and during elicitation of the CSAR evoked by electrical stimulation of the cardiac afferent sympathetic nerves in sino-aortic denervated and cervical vagotomized rats. A cannula was inserted into the left RVLM for microinjection of NO synthase inhibitor, S-methyl-L-thiocitruline (MeTC) or NO donor, S-nitroso-N-acetyl-penicillamine (SNAP). The CSAR was tested by electrical stimulation (5, 10, 20 and 30 Hz at 10 V for 1 ms) of the afferent cardiac sympathetic nerves. It was observed that (1) the responses of RSNA to stimulation were enhanced in rats with CHF; (2) MeTC (80 nmol) potentiated the responses of RSNA to stimulation in sham rats but not in rats with CHF; (3) SNAP (50 nmol) depressed the enhanced RSNA response to stimulation in CHF rats but had no effect in sham rats; and (4) MeTC increased the baseline RSNA and MAP only in sham rats, but SNAP inhibited the baseline RSNA and MAP in both sham and CHF rats. These results indicate that reductance of NO in the RVLM is involved in the augmentation of CSAR in CHF rats.
Guo-Qing Zhu; Xing-Ya Gao; Feng Zhang; Wei Wang
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Sheng li xue bao : [Acta physiologica Sinica]     Volume:  56     ISSN:  0371-0874     ISO Abbreviation:  Sheng Li Xue Bao     Publication Date:  2004 Feb 
Date Detail:
Created Date:  2004-02-26     Completed Date:  2004-07-22     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  20730130R     Medline TA:  Sheng Li Xue Bao     Country:  China    
Other Details:
Languages:  eng     Pagination:  47-53     Citation Subset:  IM    
Department of Physiology, Nanjing Medical University, Najing 210029, China.
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MeSH Terms
Afferent Pathways / physiopathology
Heart Failure / physiopathology
Medulla Oblongata / physiopathology*
Nitric Oxide / metabolism,  physiology*
Rats, Sprague-Dawley
Reflex / physiology*
Sympathetic Nervous System / drug effects,  physiopathology*
Reg. No./Substance:
10102-43-9/Nitric Oxide

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