Document Detail


Reduced neonatal lung function and wheezing illnesses during the first 5 years of life.
MedLine Citation:
PMID:  23143545     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Studies of reduced neonatal lung function and wheezing illnesses during childhood show conflicting results. The aim of our study was to assess the association between resistance (Rrs) and compliance (Crs) of the respiratory system by using the single occlusion technique (SOT) and prospectively collected wheezing illnesses during the first 5 years of life in a large birth cohort. SOT was performed during natural sleep before the age of 2 months. Information about wheezing illnesses was collected from the electronic patient file. 549 infants had a successful SOT measurement and complete medical records. Every kPa·L(-1)·s(-1) increase in Rrs was associated with 10% more consultations in the first 3 years of life. Every 10 mL·kPa(-1) increase in Crs was associated with a 14% reduction in consultations in the first 3 years of life, 27% in the fourth to fifth years of life, and a lower probability of having asthma at the age of 5 years (OR 0.66). Children with late-onset or persistent wheezing had significant lower Crs values than their peers. An increased neonatal resistance is associated with more wheezing illnesses during infancy, while a reduced neonatal compliance is associated with more wheezing illnesses during the first 5 years of life, a late-onset or persistent wheezing phenotype, and asthma.
Authors:
Anne C van der Gugten; Cuno S P M Uiterwaal; Nienke van Putte-Katier; Marije Koopman; Theo J M Verheij; Cornelis K van der Ent
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-11-08
Journal Detail:
Title:  The European respiratory journal     Volume:  42     ISSN:  1399-3003     ISO Abbreviation:  Eur. Respir. J.     Publication Date:  2013 Jul 
Date Detail:
Created Date:  2013-07-01     Completed Date:  2014-02-06     Revised Date:  2014-04-10    
Medline Journal Info:
Nlm Unique ID:  8803460     Medline TA:  Eur Respir J     Country:  England    
Other Details:
Languages:  eng     Pagination:  107-15     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Asthma / diagnosis,  physiopathology*
Child, Preschool
Female
Follow-Up Studies
Humans
Infant
Infant, Newborn
Longitudinal Studies
Lung / physiopathology*
Male
Phenotype
Prospective Studies
Respiratory Function Tests
Respiratory Sounds / diagnosis,  physiopathology*
Treatment Outcome
Comments/Corrections
Comment In:
Eur Respir J. 2014 Mar;43(3):919-21   [PMID:  24585873 ]
Eur Respir J. 2014 Mar;43(3):921-2   [PMID:  24585874 ]

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