Document Detail

Reduced neonatal lung function and wheezing illnesses during the first 5 years of life.
MedLine Citation:
PMID:  23143545     Owner:  NLM     Status:  MEDLINE    
Studies of reduced neonatal lung function and wheezing illnesses during childhood show conflicting results. The aim of our study was to assess the association between resistance (Rrs) and compliance (Crs) of the respiratory system by using the single occlusion technique (SOT) and prospectively collected wheezing illnesses during the first 5 years of life in a large birth cohort. SOT was performed during natural sleep before the age of 2 months. Information about wheezing illnesses was collected from the electronic patient file. 549 infants had a successful SOT measurement and complete medical records. Every kPa·L(-1)·s(-1) increase in Rrs was associated with 10% more consultations in the first 3 years of life. Every 10 mL·kPa(-1) increase in Crs was associated with a 14% reduction in consultations in the first 3 years of life, 27% in the fourth to fifth years of life, and a lower probability of having asthma at the age of 5 years (OR 0.66). Children with late-onset or persistent wheezing had significant lower Crs values than their peers. An increased neonatal resistance is associated with more wheezing illnesses during infancy, while a reduced neonatal compliance is associated with more wheezing illnesses during the first 5 years of life, a late-onset or persistent wheezing phenotype, and asthma.
Anne C van der Gugten; Cuno S P M Uiterwaal; Nienke van Putte-Katier; Marije Koopman; Theo J M Verheij; Cornelis K van der Ent
Related Documents :
10999865 - Respiratory syncytial virus infection in high risk infants and the potential impact of ...
10789925 - Respiratory distress in a neonate with an enlarged thymus.
15117725 - Hypoxic control of the development of the surfactant system in the chicken: evidence fo...
21494995 - The yield of early postnatal ultrasound scan in neonates with documented antenatal hydr...
10601935 - Nucleated red blood cell count at birth as an index of perinatal brain damage.
21135565 - Rethinking classification of prematurity: a new clinical algorithm that improves etiolo...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-11-08
Journal Detail:
Title:  The European respiratory journal     Volume:  42     ISSN:  1399-3003     ISO Abbreviation:  Eur. Respir. J.     Publication Date:  2013 Jul 
Date Detail:
Created Date:  2013-07-01     Completed Date:  2014-02-06     Revised Date:  2014-04-10    
Medline Journal Info:
Nlm Unique ID:  8803460     Medline TA:  Eur Respir J     Country:  England    
Other Details:
Languages:  eng     Pagination:  107-15     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Asthma / diagnosis,  physiopathology*
Child, Preschool
Follow-Up Studies
Infant, Newborn
Longitudinal Studies
Lung / physiopathology*
Prospective Studies
Respiratory Function Tests
Respiratory Sounds / diagnosis,  physiopathology*
Treatment Outcome
Comment In:
Eur Respir J. 2014 Mar;43(3):919-21   [PMID:  24585873 ]
Eur Respir J. 2014 Mar;43(3):921-2   [PMID:  24585874 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Criteria for clinical stability in hospitalised patients with community-acquired pneumonia.
Next Document:  Outcome of non-cardiac, non-obstetric surgery in patients with pulmonary arterial hypertension: resu...