| Reduced neonatal lung function and wheezing illnesses during the first five years of life. | |
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MedLine Citation:
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PMID: 23143545 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Studies about reduced neonatal lung function and wheezing illnesses during childhood showed conflicting results. The aim of this study was to assess the association between resistance and compliance of the respiratory system (Rrs/Crs) by using the single occlusion technique (SOT) and prospectively collected wheezing illnesses during the first 5 years of life in a large birth cohort.SOT was performed during natural sleep before the age of 2 months. Information about wheezing illnesses was collected from the electronic patient file.549 infants had successful SOT measurement and complete medical records. Every kPa·l(-1)·s(-1) increase in Rrs was associated with 10% more consultations in the first 3 years of life. Every 10 mL·kPa(-1) increase in Crs was associated with a 14% reduction of consultations in the first 3 years of life, 27% in the 4(th)-5(th) year of life, and a lower probability of having asthma at the age of 5 (OR=0.66). Children with late-onset or persistent wheezing had significant lower Crs values than their peers.An increased neonatal resistance is associated with more wheezing illnesses during infancy, while a reduced neonatal compliance is associated with more wheezing illnesses during the first 5 years of life, a late-onset or persistent wheezing phenotype, and asthma. |
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Authors:
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Anne C van der Gugten; Cuno S P M Uiterwaal; Nienke van Putte-Katier; Marije Koopman; Theo J M Verheij; Cornelis K van der Ent |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-11-8 |
Journal Detail:
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Title: The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology Volume: - ISSN: 1399-3003 ISO Abbreviation: Eur. Respir. J. Publication Date: 2012 Nov |
Date Detail:
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Created Date: 2012-11-12 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8803460 Medline TA: Eur Respir J Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Wilhelmina Children's Hospital, University Medical Centre Utrecht, Utrecht, the Netherlands. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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