Document Detail


Reduced muscle oxidative capacity is independent of O2 availability in elderly people.
MedLine Citation:
PMID:  22760857     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Impaired O2 transport to skeletal muscle potentially contributes to the decline in aerobic capacity with aging. Thus, we examined whether (1) skeletal muscle oxidative capacity decreases with age and (2) O2 availability or mitochondrial capacity limits the maximal rate of mitochondrial ATP synthesis in vivo in sedentary elderly individuals. We used (31)P-magnetic resonance spectroscopy ((31)P-MRS) to examine the PCr recovery kinetics in six young (26 ± 10 years) and six older (69 ± 3 years) sedentary subjects following 4 min of dynamic plantar flexion exercise under different fractions of inspired O2 (FiO2, normoxia 0.2; hyperoxia 1.0). End-exercise pH was not significantly different between old (7.04 ± 0.10) and young (7.05 ± 0.04) and was not affected by breathing hyperoxia (old 7.08 ± 0.08, P > 0.05 and young 7.05 ± 0.03). Likewise, end-exercise PCr was not significantly different between old (19 ± 4 mM) and young (24 ± 5 mM) and was not changed in hyperoxia. The PCr recovery time constant was significantly longer in the old (36 ± 9 s) compared to the young in normoxia (23 ± 8 s, P < 0.05) and was not significantly altered by breathing hyperoxia in both the old (35 ± 9 s) and young (29 ± 10 s) groups. Therefore, this study reveals that the muscle oxidative capacity of both sedentary young and old individuals is independent of O2 availability and that the decline in oxidative capacity with age is most likely due to limited mitochondrial content and/or mitochondrial dysfunction and not O2 availability.
Authors:
Gwenael Layec; Luke J Haseler; Russell S Richardson
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2012-07-04
Journal Detail:
Title:  Age (Dordrecht, Netherlands)     Volume:  35     ISSN:  1574-4647     ISO Abbreviation:  Age (Dordr)     Publication Date:  2013 Aug 
Date Detail:
Created Date:  2013-07-09     Completed Date:  2013-10-17     Revised Date:  2014-08-10    
Medline Journal Info:
Nlm Unique ID:  101250497     Medline TA:  Age (Dordr)     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  1183-92     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aging / physiology*
Exercise / physiology*
Humans
Magnetic Resonance Spectroscopy / methods
Male
Middle Aged
Mitochondria, Muscle / metabolism*
Muscle, Skeletal / physiology*
Oxidation-Reduction
Oxygen / analysis*
Oxygen Consumption
Chemical
Reg. No./Substance:
S88TT14065/Oxygen
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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