Document Detail

Reduced metaboreflex control of blood pressure during exercise in individuals with intellectual disability: A possible contributor to exercise intolerance.
MedLine Citation:
PMID:  23000635     Owner:  NLM     Status:  Publisher    
The aim was to investigate the hemodynamic responses to isometric handgrip exercise (HG) and examine the role of the muscle metaboreflex in the exercise pressor response in individuals with intellectual disability (IID) and non-disabled control subjects. Eleven males with mild-moderate intellectual disabilities and eleven non-disabled males performed a testing protocol involving 3-min periods of baseline, HG exercise (at 30% MVC), circulatory occlusion, and recovery. The same protocol was repeated without occlusion. At baseline, no differences were detected between groups in beat-to-beat mean arterial pressure (MAP), heart rate (HR), stroke volume, and peripheral resistance. IID were able to sustain an exercise MAP response at comparable levels to the control group exerting similar peripheral resistance; however, IID exhibited a blunted chronotropic response to HG and a diminished exercise vagal withdrawal compared to controls. During occlusion, IID exhibited a lower pressor response than their control peers, associated with a lower increase in peripheral resistance during this task. In conclusion, although intellectual disabilities can be the consequence of many different genes, IID share common deficits in the chronotropic response to exercise and a blunted metaboreflex-induced pressor response.
K Dipla; A Zafeiridis; S Papadopoulos; M Koskolou; N Geladas; I S Vrabas
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-9-18
Journal Detail:
Title:  Research in developmental disabilities     Volume:  34     ISSN:  1873-3379     ISO Abbreviation:  Res Dev Disabil     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-9-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8709782     Medline TA:  Res Dev Disabil     Country:  -    
Other Details:
Languages:  ENG     Pagination:  335-343     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
Laboratory of Exercise Physiology and Biochemistry, Department of Physical Education and Sports Science at Serres, Aristotle University of Thessaloniki, Agios Ioannis, Serres 62110, Greece. Electronic address:
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