Document Detail


Reduced maternal serum concentrations of angiopoietin-2 in the first trimester precede intrauterine growth restriction associated with placental insufficiency.
MedLine Citation:
PMID:  17949380     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of this study was to investigate whether maternal serum levels of angiopoietin-2 (Ang-2) and pregnancy-associated plasma protein A (PAPP-A) are associated with subsequent intrauterine growth restriction (IUGR). Ang-2 was measured in 29 nonpregnant and 44 pregnant women at 10-13 weeks of gestation. The median concentration of Ang-2 was 26.61 ng/ml in normal pregnant women compared with 1.71 ng/ml in nonpregnant controls (P < 0.01). Women who subsequently developed severe IUGR had lower levels of Ang-2 compared with normal pregnant controls (P < 0.01). PAPP-A levels were similar in all pregnant groups. These findings suggest that Ang-2 should be evaluated for its ability to predict pregnancies that later are affected by IUGR.
Authors:
Y Wang; V Tasevski; E M Wallace; E D Gallery; J M Morris
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  BJOG : an international journal of obstetrics and gynaecology     Volume:  114     ISSN:  1471-0528     ISO Abbreviation:  BJOG     Publication Date:  2007 Nov 
Date Detail:
Created Date:  2007-10-22     Completed Date:  2007-11-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100935741     Medline TA:  BJOG     Country:  England    
Other Details:
Languages:  eng     Pagination:  1427-31     Citation Subset:  AIM; IM    
Affiliation:
Perinatal Research Group, Kolling Institute of Medical Research, University of Sydney, Department of Obstetrics and Gynaecology, Royal North Shore Hospital, St Leonards, New South Wales, Australia.
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MeSH Terms
Descriptor/Qualifier:
Angiopoietin-2 / metabolism*
Biological Markers / metabolism
Birth Weight
Female
Fetal Growth Retardation / diagnosis*,  etiology
Humans
Placental Insufficiency / blood*
Pregnancy
Pregnancy Trimester, First
Pregnancy-Associated Plasma Protein-A / metabolism
Chemical
Reg. No./Substance:
0/Angiopoietin-2; 0/Biological Markers; EC 3.4.24.-/Pregnancy-Associated Plasma Protein-A

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