Document Detail

Reduced lipogenesis in rats fed a high-protein, carbohydrate-free diet: participation of liver and four adipose depots.
MedLine Citation:
PMID:  1342218     Owner:  NLM     Status:  MEDLINE    
1. Rates of in vivo fatty acid (FA) synthesis were assessed with 3H2O in carcass, liver, intestine, muscle and four adipose depots from rats fed a high-protein, carbohydrate-free diet (70% casein, 8% fat, w/w) or a balanced diet (66% carbohydrate, 17% casein, 8% fat) for 25-30 days. 2. Rats adapted to the high protein (HP) diet showed a marked reduction of total FA synthesis from all carbon sources, which was due to a decreased synthesis of triacylglycerols. Rates of phospholipid-fatty acid synthesis in both carcass and liver were not affected by the diet. Rates of triacylglycerol-fatty acid (TAG-FA) synthesis were markedly reduced in adipose tissue from four different sites: epididymal (79%), retroperitoneal (78%), subcutaneous (65%) and intermuscular (82%). 3. In rats fed the balanced control diet, TAG-FA synthesis in adipose tissue accounted for about 75% of synthesis in whole carcass, whereas it was reduced to 36% in rats under the HP regimen. 4. Although hepatic lipogenesis was also reduced in HP-fed rats, the contribution of the liver to total TAG-FA synthesis was approximately the same in HP (24%) and control (20%) rats, whereas the contribution of adipose tissue was only 26% in HP-fed animals compared to 57% in controls. 5. Force-feeding fed rats with components of their own diets resulted in a significant (100%) increase of liver TAG-FA synthesis in animals fed the control diet, but did not significantly affect liver lipogenesis in HP rats.
L M Botion; I C Kettelhut; R H Migliorini
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica ... [et al.]     Volume:  25     ISSN:  0100-879X     ISO Abbreviation:  Braz. J. Med. Biol. Res.     Publication Date:  1992  
Date Detail:
Created Date:  1994-02-10     Completed Date:  1994-02-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8112917     Medline TA:  Braz J Med Biol Res     Country:  BRAZIL    
Other Details:
Languages:  eng     Pagination:  419-28     Citation Subset:  IM    
Departamentos de Bioquímica e Fisiologia, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Brazil.
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MeSH Terms
Adipose Tissue / metabolism*
Dietary Carbohydrates
Dietary Proteins / administration & dosage*,  metabolism
Fatty Acids / biosynthesis*
Liver / metabolism*
Rats, Wistar
Triglycerides / biosynthesis*
Reg. No./Substance:
0/Dietary Carbohydrates; 0/Dietary Proteins; 0/Fatty Acids; 0/Triglycerides

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