| Reduced lipid peroxidation and ischemia-reperfusion injury after lung transplantation using low-potassium dextran solution for lung preservation. | |
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MedLine Citation:
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PMID: 9351605 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Ischemia-reperfusion injury is one of the significant problems in clinical lung transplantation. We investigated the effect of lung preservation with Euro-Collins solution (EC group) or low-potassium dextran solution (LPD group) on lipid peroxidation and ischemia-reperfusion injury in a pig model of lung allotransplantation. The donor lungs were preserved at 4 degrees C for 18 h. Left-sided single lung transplantation was performed, followed by 6 h of reperfusion. Lipid peroxidation was measured as thiobarbituric acid-reactive materials (TBARM) in bronchoalveolar lavage (BAL) fluid and effluent solutions from pulmonary artery (Effluent). After 18 h of ischemia, the LPD group showed lower TBARM in BAL and Effluent than the EC group (p < 0.05). After ischemia plus reperfusion, lung wetto-dry weight ratios and TBARM levels in BAL in the LPD group were lower than those of the EC group (p < 0.05). Lung wet-to-dry weight ratios correlated with TBARM levels in BAL (p < 0.05, r = 0.50). We conclude lipid peroxidation in BAL and Effluent may reflect the degree of ischemia-reperfusion injury, and lung preservation with LPD can reduce lipid peroxidation and lung injury as compared with EC. |
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Authors:
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F Sakamaki; H Hoffmann; C Müller; H Dienemann; K Messmer; F W Schildberg |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: American journal of respiratory and critical care medicine Volume: 156 ISSN: 1073-449X ISO Abbreviation: Am. J. Respir. Crit. Care Med. Publication Date: 1997 Oct |
Date Detail:
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Created Date: 1997-11-18 Completed Date: 1997-11-18 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9421642 Medline TA: Am J Respir Crit Care Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1073-81 Citation Subset: AIM; IM |
Affiliation:
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Department of Surgery and Institute for Surgical Research, Klinikum Grosshadern, Ludwig-Maximilians-Universität München, Munich, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bronchoalveolar Lavage Fluid / chemistry Dextrans / pharmacology Glucose / pharmacology Hemodynamics Hypertonic Solutions / pharmacology Leukocyte Count Lipid Peroxidation / drug effects*, physiology Lung Transplantation / adverse effects* Neutrophils / pathology Organ Preservation / methods* Organ Preservation Solutions / pharmacology* Potassium Reperfusion Injury / etiology, physiopathology, prevention & control* Swine Thiobarbituric Acid Reactive Substances / analysis |
| Chemical | |
Reg. No./Substance:
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0/Euro-Collins' solution; 0/Hypertonic Solutions; 0/Organ Preservation Solutions; 0/Thiobarbituric Acid Reactive Substances; 0/low potassium dextran glucose solution; 50-99-7/Glucose; 7440-09-7/Potassium; 9004-54-0/Dextrans |
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