Document Detail

Reduced lipid peroxidation and ischemia-reperfusion injury after lung transplantation using low-potassium dextran solution for lung preservation.
MedLine Citation:
PMID:  9351605     Owner:  NLM     Status:  MEDLINE    
Ischemia-reperfusion injury is one of the significant problems in clinical lung transplantation. We investigated the effect of lung preservation with Euro-Collins solution (EC group) or low-potassium dextran solution (LPD group) on lipid peroxidation and ischemia-reperfusion injury in a pig model of lung allotransplantation. The donor lungs were preserved at 4 degrees C for 18 h. Left-sided single lung transplantation was performed, followed by 6 h of reperfusion. Lipid peroxidation was measured as thiobarbituric acid-reactive materials (TBARM) in bronchoalveolar lavage (BAL) fluid and effluent solutions from pulmonary artery (Effluent). After 18 h of ischemia, the LPD group showed lower TBARM in BAL and Effluent than the EC group (p < 0.05). After ischemia plus reperfusion, lung wetto-dry weight ratios and TBARM levels in BAL in the LPD group were lower than those of the EC group (p < 0.05). Lung wet-to-dry weight ratios correlated with TBARM levels in BAL (p < 0.05, r = 0.50). We conclude lipid peroxidation in BAL and Effluent may reflect the degree of ischemia-reperfusion injury, and lung preservation with LPD can reduce lipid peroxidation and lung injury as compared with EC.
F Sakamaki; H Hoffmann; C Müller; H Dienemann; K Messmer; F W Schildberg
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of respiratory and critical care medicine     Volume:  156     ISSN:  1073-449X     ISO Abbreviation:  Am. J. Respir. Crit. Care Med.     Publication Date:  1997 Oct 
Date Detail:
Created Date:  1997-11-18     Completed Date:  1997-11-18     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9421642     Medline TA:  Am J Respir Crit Care Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1073-81     Citation Subset:  AIM; IM    
Department of Surgery and Institute for Surgical Research, Klinikum Grosshadern, Ludwig-Maximilians-Universität München, Munich, Germany.
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MeSH Terms
Bronchoalveolar Lavage Fluid / chemistry
Dextrans / pharmacology
Glucose / pharmacology
Hypertonic Solutions / pharmacology
Leukocyte Count
Lipid Peroxidation / drug effects*,  physiology
Lung Transplantation / adverse effects*
Neutrophils / pathology
Organ Preservation / methods*
Organ Preservation Solutions / pharmacology*
Reperfusion Injury / etiology,  physiopathology,  prevention & control*
Thiobarbituric Acid Reactive Substances / analysis
Reg. No./Substance:
0/Euro-Collins' solution; 0/Hypertonic Solutions; 0/Organ Preservation Solutions; 0/Thiobarbituric Acid Reactive Substances; 0/low potassium dextran glucose solution; 50-99-7/Glucose; 7440-09-7/Potassium; 9004-54-0/Dextrans

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