| Reduced levels of interleukin-1 receptor antagonist in the cerebrospinal fluid in patients with West syndrome. | |
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MedLine Citation:
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PMID: 19375283 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We measured the levels of pro- and anti-inflammatory cytokines in the cerebrospinal fluid (CSF) of 24 patients with West syndrome to clarify whether inflammatory cytokines were involved in the pathophysiology of West syndrome. There was no significant elevation of any of the three pro-inflammatory cytokines, interleukin (IL)-1beta, IL-6, and tumor necrosis factor-alpha, in patients with West syndrome as compared with those in controls. However, level of anti-inflammatory cytokine, IL-1 receptor antagonist was significantly decreased in the CSF of patients with West syndrome. Further study is needed to elucidate whether an immune system disturbance is involved in the pathophysiology of West syndrome. |
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Authors:
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Kazuhiro Haginoya; Rie Noguchi; Yajuan Zhao; Mitsutoshi Munakata; Hiroyuki Yokoyama; Soichiro Tanaka; Naomi Hino-Fukuyo; Mitsugu Uematsu; Katsuya Yamamoto; Masaru Takayanagi; Kazuie Iinuma; Shigeru Tsuchiya |
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Publication Detail:
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Type: Journal Article Date: 2009-04-16 |
Journal Detail:
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Title: Epilepsy research Volume: 85 ISSN: 1872-6844 ISO Abbreviation: Epilepsy Res. Publication Date: 2009 Aug |
Date Detail:
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Created Date: 2009-07-21 Completed Date: 2009-09-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8703089 Medline TA: Epilepsy Res Country: Netherlands |
Other Details:
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Languages: eng Pagination: 314-7 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, Tohoku University School of Medicine, Sendai 980-8574, Japan. khaginoya@silk.ocn.ne.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Cytokines
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cerebrospinal fluid Female Humans Infant Interleukin 1 Receptor Antagonist Protein / cerebrospinal fluid* Interleukin-1beta / cerebrospinal fluid Interleukin-6 / cerebrospinal fluid Male Meningitis, Aseptic / cerebrospinal fluid Spasms, Infantile / cerebrospinal fluid* Tumor Necrosis Factor-alpha / cerebrospinal fluid |
| Chemical | |
Reg. No./Substance:
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0/Cytokines; 0/IL1RN protein, human; 0/Interleukin 1 Receptor Antagonist Protein; 0/Interleukin-1beta; 0/Interleukin-6; 0/Tumor Necrosis Factor-alpha |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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