| Reduced levels of anti-MDA LDL antibodies in patients with carbohydrate metabolism disorders. | |
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MedLine Citation:
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PMID: 22239020 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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BACKGROUND: Diabetic patients undergoing percutaneous coronary intervention (PCI) have a worse prognosis than non-diabetic patients. The anti-oxidized LDL antibodies (anti-LDLox ab) have recently been suggested to be protective against the development of diabetes. The aim of this study was to compare the levels of IgG and IgM anti-oxidized LDL antibodies with reference to the new diagnostic criteria for carbohydrate metabolism disorders after an oral glucose tolerance test (OGTT) in hospitalized patients scheduled to undergo percutaneous coronary intervention. METHODS: We undertook a cross-sectional study of 110 patients undergoing PCI. The patients were classified as being normal (oral glucose test tolerance normal, OGTT-N), or having impaired glucose tolerance (IGT) or type 2 diabetes mellitus (T2DM) according to their glucose levels at baseline and after an OGTT. RESULTS: An inverse slope was found in the levels of IgG anti-oxidized LDL antibodies between the OGTT-N patients (optical density (OD) = 0.109) and the patients with IGT (OD = 0.099) or T2DM (OD = 0.084) (p = 0.019). An inverse correlation was also detected between the levels of IgG anti-oxidized LDL antibodies and baseline glycemia (r = -0.23, p = 0.018). CONCLUSIONS: Patients with coronary disease and carbohydrate metabolism disorders have much lower levels of IgG anti-oxidized LDL antibodies than normoglycemic patients. |
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Authors:
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Lourdes Garrido-Sánchez; J M García-Pinilla; Manuel Jiménez-Navarro; Julia Fernández-Pastora; Juan H Alonso-Briales; Jose M Hernández-Garcia; Eduardo De-Teresa-Galván; Francisco J Tinahones |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Clinical laboratory Volume: 57 ISSN: 1433-6510 ISO Abbreviation: Clin. Lab. Publication Date: 2011 |
Date Detail:
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Created Date: 2012-01-13 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9705611 Medline TA: Clin Lab Country: Germany |
Other Details:
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Languages: eng Pagination: 901-7 Citation Subset: IM |
Affiliation:
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CIBERDEM, Hospital Universitari Joan XXIII, IISPV, Tarragona, Spain. lourgarrido@gmail.com |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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