Document Detail

Reduced left atrial function on exercise in patients with heart failure and normal ejection fraction.
MedLine Citation:
PMID:  20584857     Owner:  NLM     Status:  MEDLINE    
AIMS: The cardinal symptom of heart failure with a normal ejection fraction (HFNEF) is exertional dyspnoea. The authors hypothesised that failure of left atrial (LA) compensatory mechanism particularly on exercise contributes to the genesis of symptoms in HFNEF patients.
METHODS AND RESULTS: Fifty HFNEF patients, 15 asymptomatic hypertensive subjects and 30 healthy controls underwent rest and submaximal exercise echocardiography. Rest and exercise systolic, early diastolic and late diastolic (Am) mitral annular velocities were assessed using colour tissue Doppler echocardiography. Left atrial functional reserve index was calculated. Am at rest was comparable between all three groups, but exercise Am was significantly lower in HFNEF compared with hypertensive subjects and healthy controls resulting in a lower LA functional reserve index (0.84 (1.34) vs 2.39 (1.27) and 1.81 (1.39), p<0.001). LA volume index was significantly higher in HFNEF patients (30.4 (9.2) vs 27.9 (6.3) and 23.2 (7.1) ml/m(2), p=0.002). There was a significant correlation between Am on exercise with peak VO(2) max (r=0.514, p<0.001) and E/Em on exercise (r=-0.547, p<0.001). Area under the receiver operating characteristic for Am on exercise was 0.768 (95% CI=0.660 to 0.877).
CONCLUSION: HFNEF patients have reduced LA function on exercise in addition to left ventricular systolic and diastolic dysfunctions. Reduced LA function probably contributes significantly to exercise intolerance and breathlessness in HFNEF patients.
Y T Tan; F Wenzelburger; E Lee; P Nightingale; G Heatlie; F Leyva; J E Sanderson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Heart (British Cardiac Society)     Volume:  96     ISSN:  1468-201X     ISO Abbreviation:  Heart     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-06-29     Completed Date:  2010-11-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9602087     Medline TA:  Heart     Country:  England    
Other Details:
Languages:  eng     Pagination:  1017-23     Citation Subset:  AIM; IM    
Department of Cardiovascular Medicine, University of Birmingham, Birmingham, UK.
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MeSH Terms
Atrial Function, Left / physiology*
Case-Control Studies
Dyspnea / etiology,  physiopathology,  ultrasonography
Exercise Tolerance / physiology*
Heart Failure, Diastolic / complications,  physiopathology*,  ultrasonography
Hypertension / complications,  physiopathology*,  ultrasonography
Respiratory Function Tests
Stroke Volume / physiology*
Grant Support
//British Heart Foundation

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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