| Reduced insulin growth factor I concentrations in iron-overloaded beta thalassaemic patients with normal growth hormone secretion and liver function. | |
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MedLine Citation:
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PMID: 16462706 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We selected 92 subjects (46 females and 46 males), aged 10-15 years, from the Haematology and Endocrine Clinic of Shiraz University, Iran. Forty-six were beta thalassaemia patients (beta-Th) with short stature, 23 had idiopathic short stature (ISS) and 23 were healthy children with a standing height between the 10th and 95th percentile. Growth hormone (GH) secretion was normal in 23 beta-Th patients and reduced in the remaining 23 patients. A low insulin growth factor I (IGF-I) was found in 73.9% of beta-Th patients with GH deficiency, 56.5% of beta-Th patients with normal GH secretion to stimulation test and 8.7% of children with ISS. The reduced IGF-I concentration in beta-Th patients with normal GH secretion may be explained by partial insensitivity to GH (GHIS), neurosecretory dysfunction, low bioactive GH or increased proportion of circulating, non-22-kDa GH isoform. The possibility of GHIS in beta-Th patients with short stature indicates that higher doses of rechGH may be required to obtain an improvement in growth velocity in beta-Th patients. |
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Authors:
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Hamdollah Karamifar; Mehran Karimi; Gholamhossein Amirhakimi; Mohammadreza Sharbatialaei; Vincenzo De Sanctis |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Pediatric endocrinology reviews : PER Volume: 2 Suppl 2 ISSN: 1565-4753 ISO Abbreviation: Pediatr Endocrinol Rev Publication Date: 2004 Dec |
Date Detail:
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Created Date: 2006-02-07 Completed Date: 2006-03-09 Revised Date: 2008-04-09 |
Medline Journal Info:
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Nlm Unique ID: 101202124 Medline TA: Pediatr Endocrinol Rev Country: Israel |
Other Details:
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Languages: eng Pagination: 256-8 Citation Subset: IM |
Affiliation:
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Endocrine Department, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran. karimim@sums.ac.ir |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Alanine Transaminase / blood Body Height Child Child, Preschool Deferoxamine / pharmacology Female Ferritins / blood Human Growth Hormone / metabolism*, secretion Humans Infant Insulin-Like Growth Factor I / metabolism* Iron Overload / enzymology, metabolism* Liver / enzymology, metabolism Male beta-Thalassemia / blood, enzymology, metabolism* |
| Chemical | |
Reg. No./Substance:
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12629-01-5/Human Growth Hormone; 67763-96-6/Insulin-Like Growth Factor I; 70-51-9/Deferoxamine; 9007-73-2/Ferritins; EC 2.6.1.2/Alanine Transaminase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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