Document Detail


Reduced incidence of rabbit endometrial neoplasia with levonorgestrel implant.
MedLine Citation:
PMID:  3124619     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To test the hypothesis that progestogens protect against the development of endometrial neoplasia, we placed polydimethylsiloxane implants (levonorgestrel or inert) into the right uterine horn at random in 114 old female rabbits. Cross-sectional uterine biopsy specimens were taken from both horns at the time of implantation and at 6, 12, and 24 months thereafter. Twenty-nine levonorgestrel-treated and 33 controls survived to the completion of the study. The incidence of endometrial neoplasia of 17.2% in the group treated with levonorgestrel was significantly less (p less than 0.05) than the 42.4% incidence observed in the control does. Before the completion of the study, one levonorgestrel-treated doe died and was found to have an endometrial tumor. When the findings of this doe are included in the report, the statistical significance is marginally lost. No endometrial neoplasia was found in the eight does with serum levonorgestrel concentrations greater than 0.12 ng/ml. Only one of the five tumors in the levonorgestrel-treated group occurred in the horn containing the levonorgestrel implant, which suggests that a dose effect is likely. Treatment with levonorgestrel decreases the incidence of endometrial neoplasia in rabbits. This finding gives further credence to the use of progestogen supplementation in women at risk for developing endometrial neoplasia.
Authors:
J A Nisker; M E Kirk; J T Nunez-Troconis
Related Documents :
20478369 - Induction of cytotoxicity and apoptosis in mouse blastocysts by silver nanoparticles.
18199579 - Inactivation of nuclear wnt-beta-catenin signaling limits blastocyst competency for imp...
6864659 - Effects of relaxin on the intrauterine distribution and antimesometrial positioning and...
20459759 - A comparative genome analysis of gene expression reveals different regulatory mechanism...
19896659 - Involvement of connexin 43 in the acupuncture effect of improving rat blastocyst implan...
4382009 - Glucose 6-phosphate-dehydrogenase activity in the preimplantation mouse embryo.
18485559 - Effects of light exposure time on composite resin hardness after root reinforcement usi...
20408769 - Implantation of functionalized thermally gelling xyloglucan hydrogel within the brain: ...
15792209 - Component position following total hip arthroplasty through a miniinvasive posterolater...
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  158     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  1988 Feb 
Date Detail:
Created Date:  1988-03-21     Completed Date:  1988-03-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  300-3     Citation Subset:  AIM; IM    
Affiliation:
Department of Obstetrics and Gynecology, University of Western Ontario, London, Canada.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Biopsy
Dimethylpolysiloxanes
Drug Implants
Female
Levonorgestrel
Norgestrel / administration & dosage,  therapeutic use*
Rabbits
Random Allocation
Uterine Neoplasms / prevention & control*
Chemical
Reg. No./Substance:
0/Dimethylpolysiloxanes; 0/Drug Implants; 6533-00-2/Norgestrel; 797-63-7/Levonorgestrel

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Efficacy of intranasal or subcutaneous luteinizing hormone-releasing hormone agonist inhibition of o...
Next Document:  The role of carbon dioxide in the generation of human fetal breathing movements.