| Reduced incidence of hyaline membrane disease in extremely premature infants following delay of delivery in mother with preterm labor: use of ritodrine and betamethasone. | |
| | |
MedLine Citation:
|
PMID: 3532016 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Data from two groups of infants (24 to 28 weeks' gestational age) excluded from a controlled trial of the use of calf lung surfactant extract for the prevention of hyaline membrane disease are reported. The two groups were excluded from the trial because the mothers had received betamethasone for greater than 24 hours prior to delivery or because, on admission to the hospital, labor was too far advanced for proper informed consent to enter the trial. Attempts were made to delay delivery of threatened premature labor by the use of ritodrine in all mothers without evidence of infection, heavy vaginal bleeding, or severe preeclampsia and to induce surfactant production by maternal injection of betamethasone. A prospective scoring system and respiratory support variables were used to compare the groups. Infants born to mothers who successfully completed this regimen had a 28% incidence of hyaline membrane disease v a 68% incidence in infants in whose mothers it was unsuccessful due to inability to stop advanced labor (P = .001). Inspired oxygen, mean airway pressure, and ventilator rate were lower and the ventilator efficiency index was higher in the treated group during the first 48 hours of life. An aggressive approach to postpone premature delivery and to induce surfactant production by using tocolysis and a regimen of glucocorticoids reduces the incidence of hyaline membrane disease in very premature infants, 24 to 28 weeks' gestation. |
| | |
Authors:
|
M S Kwong; E A Egan |
Related Documents
:
|
6336136 - Bacterial vaginosis during pregnancy. an association with prematurity and postpartum co... 2304706 - Labor patterns in women with previous cesareans. 17091416 - Acupuncture administered after spontaneous rupture of membranes at term significantly r... 17122236 - Combined spinal epidural does not cause a higher sensory block than single shot spinal ... 22691696 - Risk factors and prognosis for neonatal sepsis in southeastern mexico: analysis of a fo... 18518836 - Appropriate face models for evaluating drug delivery in the laboratory: the current sit... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Pediatrics Volume: 78 ISSN: 0031-4005 ISO Abbreviation: Pediatrics Publication Date: 1986 Nov |
Date Detail:
|
Created Date: 1986-11-19 Completed Date: 1986-11-19 Revised Date: 2005-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 0376422 Medline TA: Pediatrics Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 767-74 Citation Subset: AIM; IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Betamethasone
/
therapeutic use* Female Humans Hyaline Membrane Disease / physiopathology, prevention & control* Infant, Newborn Intermittent Positive-Pressure Ventilation Obstetric Labor, Premature / prevention & control* Oxygen Consumption Pregnancy Respiratory Distress Syndrome, Newborn / etiology Ritodrine / therapeutic use* Sex Factors Time Factors Twins |
| Chemical | |
Reg. No./Substance:
|
26652-09-5/Ritodrine; 378-44-9/Betamethasone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Intracranial hemorrhage during extracorporeal membrane oxygenation in neonates.
Next Document: Emotional and health impact of home monitoring on mothers: a controlled prospective study.