Document Detail

Reduced immunoglobulin levels in epilepsy patients treated with levetiracetam, lamotrigine, or carbamazepine.
MedLine Citation:
PMID:  23190286     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: The aim of the study was to investigate immunoglobulin levels in patients with epilepsy using the antiepileptic drugs (AED) levetiracetam (LEV), carbamazepine (CBZ), or lamotrigine (LTG).
METHODS: A total of 211 patients and 80 controls (age: 18-45 years) of both genders were included. The patients had been treated with either LEV (n = 47), CBZ (n = 90), or LTG (n = 74) monotherapy for at least 6 months. Total concentrations of immunoglobulin G (IgG), IgG subclasses (IgG1, IgG2, IgG3, and IgG4), immunoglobulin A (IgA), and immunoglobulin M (IgM) were measured. Smoking, drinking habits, and physical activity were recorded, and body mass index (BMI) was calculated.
RESULTS: A significantly lower total IgG and IgG1 was found in both men and women treated with LTG and in men on CBZ. IgG2 and IgG4 were also lower in LTG-treated women, and IgA and IgM were lower in LTG-treated men. Patients treated with LEV did not differ from the control group.
CONCLUSIONS: Low levels of immunoglobulins were found in patients with epilepsy treated with LTG or CBZ. As our group of patients consisted of otherwise healthy young adults, one should be especially aware of a possible effect of AEDs on immunoglobulin levels when treating selected patient groups, for example immunocompromised patients. Immunoglobulin concentrations should be measured in patients treated with LTG or CBZ who experience recurrent infections, and a change in medication should be considered.
S Svalheim; U Mushtaq; M Mochol; G Luef; M Rauchenzauner; S S Frøland; E Taubøll
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta neurologica Scandinavica. Supplementum     Volume:  -     ISSN:  1600-5449     ISO Abbreviation:  Acta Neurol. Scand., Suppl.c     Publication Date:  2013  
Date Detail:
Created Date:  2012-11-29     Completed Date:  2013-05-07     Revised Date:  2013-08-21    
Medline Journal Info:
Nlm Unique ID:  0370337     Medline TA:  Acta Neurol Scand Suppl     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  11-5     Citation Subset:  IM    
Copyright Information:
© 2012 John Wiley & Sons A/S.
Department of Neurology, Oslo University Hospital - Rikshospitalet, Oslo, Norway.
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MeSH Terms
Anticonvulsants / therapeutic use*
Body Mass Index
Carbamazepine / therapeutic use
Double-Blind Method
Epilepsy / blood*,  drug therapy*
Immunoglobulins / blood*,  classification
Middle Aged
Piracetam / analogs & derivatives,  therapeutic use
Statistics, Nonparametric
Triazines / therapeutic use
Young Adult
Reg. No./Substance:
0/Anticonvulsants; 0/Immunoglobulins; 0/Triazines; 230447L0GL/etiracetam; 298-46-4/Carbamazepine; 7491-74-9/Piracetam; U3H27498KS/lamotrigine

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