Document Detail


Reduced hypoxic chemosensitivity in partially paralysed man. A new property of muscle relaxants?
MedLine Citation:
PMID:  8792879     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: It was hypothesized that non-depolarizing neuromuscular blocking agents impair hypoxic chemosensitivity in man. METHODS: In thirty randomly allocated male volunteers the hypoxic and hypercarbic ventilatory responses were measured during partial paralysis (TOF ratio 0.70) due to either atracurium (n = 10), pancuronium (n = 10) or vecuronium (n = 10). RESULTS: Hypoxic ventilatory responses were depressed by 306, 287 and 296% (mean SD) at steady-state infusion of atracurium, pancuronium and vecuronium, respectively. At a TOF ratio of > 0.90, the HVR was not different from control measurements. CONCLUSION: It is concluded that non-depolarizing neuromuscular blocking agents impair hypoxic ventilatory regulation. Further experimental studies are warranted to fully describe the mechanism(s) responsible for this interaction.
Authors:
L I Eriksson
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Acta anaesthesiologica Scandinavica     Volume:  40     ISSN:  0001-5172     ISO Abbreviation:  Acta Anaesthesiol Scand     Publication Date:  1996 May 
Date Detail:
Created Date:  1996-11-19     Completed Date:  1996-11-19     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0370270     Medline TA:  Acta Anaesthesiol Scand     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  520-3     Citation Subset:  IM    
Affiliation:
Department of Anaesthesiology and Intensive Care, Karolinska Hospital and Institute, Stockholm, Sweden.
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MeSH Terms
Descriptor/Qualifier:
Anoxia / physiopathology*
Atracurium / pharmacology
Chemoreceptor Cells / physiopathology
Humans
Hypercapnia / physiopathology
Male
Neuromuscular Blockade*
Neuromuscular Nondepolarizing Agents / pharmacology
Pancuronium / pharmacology
Respiration*
Vecuronium Bromide / pharmacology
Chemical
Reg. No./Substance:
0/Neuromuscular Nondepolarizing Agents; 0/Pancuronium; 50700-72-6/Vecuronium Bromide; 64228-79-1/Atracurium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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