Document Detail

Reduced hypoxic chemosensitivity in partially paralysed man. A new property of muscle relaxants?
MedLine Citation:
PMID:  8792879     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: It was hypothesized that non-depolarizing neuromuscular blocking agents impair hypoxic chemosensitivity in man. METHODS: In thirty randomly allocated male volunteers the hypoxic and hypercarbic ventilatory responses were measured during partial paralysis (TOF ratio 0.70) due to either atracurium (n = 10), pancuronium (n = 10) or vecuronium (n = 10). RESULTS: Hypoxic ventilatory responses were depressed by 306, 287 and 296% (mean SD) at steady-state infusion of atracurium, pancuronium and vecuronium, respectively. At a TOF ratio of > 0.90, the HVR was not different from control measurements. CONCLUSION: It is concluded that non-depolarizing neuromuscular blocking agents impair hypoxic ventilatory regulation. Further experimental studies are warranted to fully describe the mechanism(s) responsible for this interaction.
L I Eriksson
Related Documents :
7369979 - Retinal studies at 446 torr in a hypobaric chamber.
18832419 - Contribution of respiratory muscle blood flow to exercise-induced diaphragmatic fatigue...
15772499 - Effects of sildenafil on the human response to acute hypoxia and exercise.
15769449 - Gap junctional remodeling by hypoxia in cultured neonatal rat ventricular myocytes.
15086419 - Moderate hypoxia suppresses exercise-induced procoagulant changes.
22313809 - Resistance exercise enhances myofibrillar protein synthesis with graded intakes of whey...
21552729 - Immediate effect of sounded blowing exercise in the elderly voice.
21603199 - Effects of a flexibility and relaxation programme, walking, and nordic walking on parki...
8866359 - Reversible inactivations of the cerebellum prevent the extinction of conditioned nictit...
Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Acta anaesthesiologica Scandinavica     Volume:  40     ISSN:  0001-5172     ISO Abbreviation:  Acta Anaesthesiol Scand     Publication Date:  1996 May 
Date Detail:
Created Date:  1996-11-19     Completed Date:  1996-11-19     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0370270     Medline TA:  Acta Anaesthesiol Scand     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  520-3     Citation Subset:  IM    
Department of Anaesthesiology and Intensive Care, Karolinska Hospital and Institute, Stockholm, Sweden.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Anoxia / physiopathology*
Atracurium / pharmacology
Chemoreceptor Cells / physiopathology
Hypercapnia / physiopathology
Neuromuscular Blockade*
Neuromuscular Nondepolarizing Agents / pharmacology
Pancuronium / pharmacology
Vecuronium Bromide / pharmacology
Reg. No./Substance:
0/Neuromuscular Nondepolarizing Agents; 0/Pancuronium; 50700-72-6/Vecuronium Bromide; 64228-79-1/Atracurium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  PCO2 electrodes at the surface of the kidney detect ischaemia.
Next Document:  Atelectasis and pulmonary shunting during induction of general anaesthesia--can they be avoided?