Document Detail


Reduced hypotensive effect of clonidine after lesions of the nucleus tractus solitarii in rats.
MedLine Citation:
PMID:  954829     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Bilateral electrolytic lesion of the area of the nucleus tractus solitarii (NTS) in rats produced a sustained increase in blood pressure and reduced the hypotensive response to a single dose of clonidine (30 mug/kg, i.v.). The same dose of clonidine evoked a much larger drop in blood pressure in another group of rats in which an equialent increase in blood pressure was produced by bilateral section of the vagosympathetic trunks and occlusion of both carotid arteries. It is concluded that the dorsal part of the medulla oblongata in the area of NTS is an important link in the hypotensive action of clonidine.
Authors:
J Lipski; J Przybylski; E Solnicka
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of pharmacology     Volume:  38     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  1976 Jul 
Date Detail:
Created Date:  1976-11-01     Completed Date:  1976-11-01     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  19-22     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Pressure / drug effects*
Carotid Arteries / physiology
Clonidine / pharmacology*
Depression, Chemical
Female
Male
Medulla Oblongata / physiology*
Rats
Vagus Nerve / physiology
Chemical
Reg. No./Substance:
4205-90-7/Clonidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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