| Reduced gray matter volume of dorsal cingulate cortex in patients with obsessive-compulsive disorder: a voxel-based morphometric study. | |
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MedLine Citation:
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PMID: 20923432 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIMS: Previous morphometric studies using magnetic resonance imaging (MRI) have revealed structural brain abnormalities in obsessive-compulsive disorder (OCD). The aim of the present study was to investigate the alterations in brain structure of patients with OCD using a voxel-based morphometry (VBM) method. METHODS: Sixteen patients with OCD free of comorbid major depression, and 32 sex- and age-matched healthy subjects underwent MRI using a 1.5-T MR scanner. OCD severity was assessed with the Yale-Brown Obsessive-Compulsive Scale (mean ± SD: 22 ± 7.6; range: 7-32). MR images were spatially normalized and segmented using the VBM5 package (http://dbm.neuro.uni-jena.de/vbm/). Statistical analysis was performed using statistical parametric mapping software. RESULTS: Significant reductions in regional gray matter volume were detected in the left caudal anterior cingulate cortex and right dorsal posterior cingulate cortex in the patients with OCD as compared to healthy controls (uncorrected, P < 0.001). No significant differences in white matter volumes were observed in any brain regions of the patients. No significant correlation between Yale-Brown Obsessive-Compulsive Scale score and regional gray matter or white matter volume was observed. CONCLUSIONS: Regional gray matter alteration in the dorsal cingulate cortex, which is suggested to play a role in non-emotional cognitive processes, may be related to the pathophysiology in OCD. |
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Authors:
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Ryohei Matsumoto; Hiroshi Ito; Hidehiko Takahashi; Tomomichi Ando; Yota Fujimura; Kazuhiko Nakayama; Yoshiro Okubo; Takayuki Obata; Kenji Fukui; Tetsuya Suhara |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Psychiatry and clinical neurosciences Volume: 64 ISSN: 1440-1819 ISO Abbreviation: Psychiatry Clin. Neurosci. Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-10-06 Completed Date: 2011-01-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9513551 Medline TA: Psychiatry Clin Neurosci Country: Australia |
Other Details:
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Languages: eng Pagination: 541-7 Citation Subset: IM |
Copyright Information:
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© 2010 The Authors. Psychiatry and Clinical Neurosciences © 2010 Japanese Society of Psychiatry and Neurology. |
Affiliation:
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Molecular Neuroimaging Group, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Diagnostic and Statistical Manual of Mental Disorders Female Functional Laterality / physiology Gyrus Cinguli / pathology* Humans Image Processing, Computer-Assisted Magnetic Resonance Imaging Male Obsessive-Compulsive Disorder / pathology* Psychiatric Status Rating Scales |
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