| Reduced gluconeogenesis and lactate clearance in Huntington's disease. | |
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MedLine Citation:
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PMID: 20727971 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We studied systemic and brain glucose and lactate metabolism in Huntington's disease (HD) patients in response to ergometer cycling. Following termination of exercise, blood glucose increased abruptly in control subjects, but no peak was seen in any of the HD patients (2.0 ± 0.5 vs. 0.0 ± 0.2mM, P < 2 × 10(-6)). No difference was seen in brain metabolism parameters. Reduced hepatic glucose output in the HD mouse model R6/2 following a lactate challenge, combined with reduced phosphoenolpyruvate carboxykinase and increased pyruvate kinase activity in the mouse liver suggest a reduced capacity for gluconeogenesis in HD, possibly contributing to the clinical symptoms of HD. We propose that blood glucose concentration in the recovery from exercise can be applied as a liver function test in HD patients. |
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Authors:
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Knud Josefsen; Signe M B Nielsen; André Campos; Thomas Seifert; Lis Hasholt; Jørgen E Nielsen; Anne Nørremølle; Niels H Skotte; Niels H Secher; Bjørn Quistorff |
Publication Detail:
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Type: Journal Article Date: 2010-08-19 |
Journal Detail:
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Title: Neurobiology of disease Volume: 40 ISSN: 1095-953X ISO Abbreviation: Neurobiol. Dis. Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-10-15 Completed Date: 2011-01-25 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9500169 Medline TA: Neurobiol Dis Country: United States |
Other Details:
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Languages: eng Pagination: 656-62 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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The Bartholin Institute, Rigshospitalet, Copenhagen, Denmark. knud@eln.dk |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Glucose / analysis* Blotting, Western Brain / metabolism* Exercise / physiology* Exercise Test / methods Female Gluconeogenesis / physiology* Humans Huntington Disease / metabolism*, physiopathology Lactic Acid / metabolism* Liver / metabolism, physiopathology Liver Function Tests / methods Male Mice Mice, Transgenic Middle Aged Reverse Transcriptase Polymerase Chain Reaction |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 50-21-5/Lactic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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