| Reduced frontal cortex inositol levels in postmortem brain of suicide victims and patients with bipolar disorder. | |
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MedLine Citation:
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PMID: 9247405 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: This study aimed to evaluate aspects of second messenger function in the brain of suicide victims and patients with bipolar disorder. METHOD: Inositol and its synthetic enzyme, inositol monophosphatase, were measured in postmortem brain samples of 10 suicide victims, eight patients with bipolar affective disorder, and 10 normal comparison subjects. RESULTS: The frontal cortex inositol levels of the suicide victims and the patients with bipolar disorder were significantly less than those of the normal comparison group. No differences in cerebellum or occipital cortex inositol levels were found among the three groups. The groups also showed no differences in inositol monophosphatase activity in any brain area. CONCLUSIONS: These results could suggest a deficiency of second messenger precursor in patients with bipolar disorder and suicide victims. |
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Authors:
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H Shimon; G Agam; R H Belmaker; T M Hyde; J E Kleinman |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The American journal of psychiatry Volume: 154 ISSN: 0002-953X ISO Abbreviation: Am J Psychiatry Publication Date: 1997 Aug |
Date Detail:
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Created Date: 1997-08-15 Completed Date: 1997-08-15 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370512 Medline TA: Am J Psychiatry Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1148-50 Citation Subset: AIM; IM |
Affiliation:
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Ministry of Health Mental Health Center, Faculty of Health Sciences, Ben-Gurion University of the Negev, Israel. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Bipolar Disorder / enzymology, metabolism* Brain / enzymology Brain Chemistry* Cerebellum / chemistry Female Frontal Lobe / chemistry Humans Inositol / analysis*, metabolism Male Middle Aged Occipital Lobe / chemistry Phosphoric Monoester Hydrolases / analysis Second Messenger Systems / physiology Suicide / statistics & numerical data* |
| Chemical | |
Reg. No./Substance:
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6917-35-7/Inositol; EC 3.1.3.-/Phosphoric Monoester Hydrolases; EC 3.1.3.25/myo-inositol-1 (or 4)-monophosphatase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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