| Reduced frequency of occlusion of aorto-pulmonary shunts in infants receiving aspirin. | |
| | |
MedLine Citation:
|
PMID: 10535826 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: Infants with severely reduced pulmonary perfusion due to complex congenital cardiac malformations are in need of an improved flow of blood to the lungs. One option for treatment is to construct a systemic-to-pulmonary arterial shunt. Although such shunts have been used since 1945, their spontaneous occlusion remains a major problem in the long-term. DESIGN: We studied all infants in whom a systemic-to-pulmonary arterial shunt had been constructed using a Gore-Tex tube graft between December 1989 and March 1996. PATIENTS: Of 46 infants undergoing construction of a shunt, 7 (15%) died within 30 days of surgery. The shunts had to be taken down in 2 infants. Thus, 37 infants were included in the study. All but three infants received Aspirin. Aspirin was discontinued on the personal decision of individual physicians. Of 22 infants, 3 never received Aspirin, and in 19 it was stopped well before undertaking subsequent surgery. Aspirin was administered continuously to 15 infants until further surgery. RESULTS: Those in whom Aspirin was discontinued, or not given, and those receiving Aspirin until further surgery, were comparable concerning their age, time of follow-up, severity of the cardiac lesions, and size and type of shunt. Partial or complete occlusion of the shunt occurred in 2 of 15 (13%) infants taking Aspirin, but was seen in 12 of 22 (54%) infants in whom Aspirin was discontinued. Of these, 3 died due to acute occlusion of the shunt. CONCLUSIONS: Aspirin reduced effectively the rate of occlusion of systemic-to-pulmonary arterial shunts, and should be continued as long as the shunt is in place. |
| | |
Authors:
|
R Motz; A Wessel; W Ruschewski; J Bürsch |
Related Documents
:
|
19158126 - Neonatal bronchopulmonary dysplasia predicts abnormal pulmonary hrct scans in long-term... 19587566 - Hypoxia in the term newborn: part three--sepsis and hypotension, neurologic, metabolic ... 15988736 - Congenital pulmonary lymphangiectasia presenting as nonimmune fetal hydrops and severe ... 19944216 - Evaluating mortality and disease severity in congenital diaphragmatic hernia using the ... 9232036 - Tobacco and children. an economic evaluation of the medical effects of parental smoking. 12012876 - Triplet births in the united states. an epidemic of high-risk pregnancies. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Cardiology in the young Volume: 9 ISSN: 1047-9511 ISO Abbreviation: Cardiol Young Publication Date: 1999 Sep |
Date Detail:
|
Created Date: 1999-11-23 Completed Date: 1999-11-23 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 9200019 Medline TA: Cardiol Young Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 474-7 Citation Subset: IM |
Affiliation:
|
Clinic for Paediatric Cardiology, Georg-August-University, Göttingen, Germany. motzrhc@aon.at |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aorta
/
surgery Arteriovenous Shunt, Surgical Aspirin / therapeutic use* Case-Control Studies Female Graft Occlusion, Vascular / prevention & control* Heart Defects, Congenital / mortality, surgery Humans Infant Male Platelet Aggregation Inhibitors / therapeutic use* Polytetrafluoroethylene Prospective Studies Pulmonary Artery / surgery Retrospective Studies |
| Chemical | |
Reg. No./Substance:
|
0/Platelet Aggregation Inhibitors; 50-78-2/Aspirin; 9002-84-0/Polytetrafluoroethylene |
| Comments/Corrections | |
Comment In:
|
Cardiol Young. 1999 Sep;9(5):462
[PMID:
10535823
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Transcatheter closure as standard treatment for most interatrial defects: experience in 200 patients...
Next Document: Unguarded mitral orifice, mirror-imaged atrial arrangement, and discordant atrioventricular connecti...