Document Detail


Reduced, free and total fractions of homocysteine and other thiol compounds in plasma from patients with renal failure.
MedLine Citation:
PMID:  7617118     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The levels of different fractions of homocysteine, cysteine and cysteinylglycine were investigated in 17 patients on chronic hemodialysis, 9 patients with reduced renal function and 4 patients with nephrotic syndrome and compared with 14 healthy subjects. Total plasma homocysteine, cysteine and cysteinylglycine were increased in the patients with reduced renal function and in those on chronic hemodialysis. The free (non-protein-bound) forms of plasma homocysteine and cysteine were significantly increased in all groups of patients. The reduced forms of plasma homocysteine and cysteine were, however, not increased in any of the patient groups; on the contrary, reduced plasma homocysteine was significantly decreased in the group of patients with reduced renal function. These findings indicate that the plasma levels of reduced forms of the thiol compounds are relatively normal and do not merely mirror the elevation of the disulfide forms. The possible relation between homocysteine and increased atherogenesis in patients with renal failure is discussed.
Authors:
B Hultberg; A Andersson; M Arnadottir
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Nephron     Volume:  70     ISSN:  0028-2766     ISO Abbreviation:  Nephron     Publication Date:  1995  
Date Detail:
Created Date:  1995-08-24     Completed Date:  1995-08-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0331777     Medline TA:  Nephron     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  62-7     Citation Subset:  IM    
Affiliation:
Department of Clinical Chemistry, University Hospital, Lund, Sweden.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Aged, 80 and over
Cysteine / blood
Dipeptides / blood
Female
Homocysteine / blood*
Humans
Kidney Failure, Chronic / blood*,  etiology,  therapy
Male
Middle Aged
Nephrotic Syndrome / blood*,  complications,  therapy
Renal Dialysis
Sulfhydryl Compounds / blood*
Chemical
Reg. No./Substance:
0/Dipeptides; 0/Sulfhydryl Compounds; 19246-18-5/cysteinylglycine; 454-28-4/Homocysteine; 52-90-4/Cysteine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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