Document Detail


Reduced food intake after jejunoileal bypass: a possible association with prolonged gastric emptying and altered gut hormone patterns.
MedLine Citation:
PMID:  9209165     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The object of this study was to examine whether eating behavior, food preference, gastric emptying, and gut hormone patterns are altered after jejunoileal bypass (JIB) in patients with severe obesity. Eight obese [mean (+/- SD) body mass index (BMI; in kg/m2) 42.9 +/- 4] subjects were studied prospectively before and 9 mo after JIB with eight age- and sex-matched normal-weight control subjects. Total energy intake, data from the universal eating monitor (VIKTOR), eating motivation measured by visual analog scales, a food-preference checklist, a forced-choice list, solid-phase gastric emptying, and postprandial concentrations of cholecystokinin, motilin, and neurotensin were studied. BMI was reduced by 29% after JIB. Compared with normal subjects, the JIB patients showed a reduced desire to eat, decreased hunger, and reduced prospective consumption before a test meal. After surgery, obese subjects selected fewer food items and showed a reduced preference for high-carbohydrate and high-fat items before a test meal. There was a trend from an accelerated toward a decelerated eating pattern in obese subjects after JIB. After JIB, gastric emptying of obese subjects was slowed and similar to that in control subjects. Obese subjects had lower postprandial cholecystokinin concentrations that were lower than those of control subjects both before and after JIB. Postprandial concentrations of neurotensin were higher after JIB. We conclude that after JIB, the desire to eat and preference for high-carbohydrate and high-fat items is reduced, resulting in decreased energy intake. That gastric emptying is prolonged and gut hormone patterns are altered with low postprandial plasma cholecystokinin and high neurotensin plasma concentrations may at least partly account for these observations.
Authors:
E Näslund; I Melin; P Grybäck; A Hägg; P M Hellström; H Jacobsson; E Theodorsson; S Rössner; L Backman
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  66     ISSN:  0002-9165     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  1997 Jul 
Date Detail:
Created Date:  1997-07-31     Completed Date:  1997-07-31     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  26-32     Citation Subset:  AIM; IM    
Affiliation:
Department of Surgery, Karolinska Institute, Danderyd Hospital, Sweden. Erik.Naslund@kir.ds.sll.se
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MeSH Terms
Descriptor/Qualifier:
Adult
Digestive System / metabolism
Eating* / physiology,  psychology
Energy Intake
Female
Food Preferences*
Gastric Emptying*
Gastrointestinal Hormones / blood*
Humans
Jejunoileal Bypass*
Male
Obesity / physiopathology*,  surgery
Postoperative Period
Postprandial Period
Reference Values
Chemical
Reg. No./Substance:
0/Gastrointestinal Hormones
Comments/Corrections
Comment In:
Am J Clin Nutr. 1997 Jul;66(1):184-5   [PMID:  9209188 ]
Am J Clin Nutr. 1997 Jul;66(1):2-7   [PMID:  9209162 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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