| Reduced folic acid, vitamin B12 and docosahexaenoic acid and increased homocysteine and cortisol in never-medicated schizophrenia patients: implications for altered one-carbon metabolism. | |
| | |
MedLine Citation:
|
PMID: 19969375 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Abnormal one-carbon metabolism has long been suggested as one of the mechanisms for neuropathology and psychopathology of schizophrenia. Variable levels of components of one-carbon metabolism (folic acid and vitamin B12) and consequent altered levels of homocysteine and phospholipid docosahexaenoic acid (DHA) have been independently reported, mostly in medicated patients. This study examined the simultaneous levels of these key components of one-carbon metabolism and its consequences in unique, medication-na?ve first-episode psychotic patients (FEP, n=31) and healthy controls (HC, n=48) matched for confounds such as race, diet and lifestyle to reduce the variability. Significantly lower levels of folate and vitamin B12 in plasma and folate in red blood cells were observed in FEP compared to HC. These reductions paralleled the significant increase in plasma homocysteine and cortisol levels. Significantly reduced levels of membrane DHA were also observed in FEP compared to HC. This study, using a unique cohort, provided a broader mechanism (disturbed folic acid-vitamin B12-DHA balance) of altered one-carbon metabolism and one of its key consequential components, an increased homocysteine level that together with cortisol, can contribute to the neuropathology of psychosis. These data may have important implications for the amelioration of psychopathology in schizophrenia. |
| | |
Authors:
|
Anvita Kale; Nilesh Naphade; Swati Sapkale; Marellasv Kamaraju; Anilkumar Pillai; Sadhana Joshi; Sahebarao Mahadik |
Related Documents
:
|
7391485 - Composition of miner's lettuce (montia perfoliata). 3998345 - Yields and nutrient content of selected fresh fruits. 16010345 - Bioactive s-alk(en)yl cysteine sulfoxide metabolites in the genus allium: the chemistry... 15234975 - Importin alpha1 (rch1) mediates nuclear translocation of thioredoxin-binding protein-2/... 412415 - Reaction of tetrahydrofolic acid with cyanate from urea solutions: formation of an inac... 22060305 - Tba test by an extractive method applied to 'paté'. |
Publication Detail:
|
Type: Journal Article Date: 2009-12-06 |
Journal Detail:
|
Title: Psychiatry research Volume: 175 ISSN: 0165-1781 ISO Abbreviation: Psychiatry Res Publication Date: 2010 Jan |
Date Detail:
|
Created Date: 2010-02-01 Completed Date: 2010-03-16 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7911385 Medline TA: Psychiatry Res Country: Ireland |
Other Details:
|
Languages: eng Pagination: 47-53 Citation Subset: IM |
Affiliation:
|
Department of Nutritional Medicine, Interactive Research School for Health Affairs, Bharati Vidyapeeth University, Pune 411043, India. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adult Case-Control Studies Docosahexaenoic Acids / blood* Erythrocytes / metabolism Female Folic Acid / blood* Homocysteine / blood* Humans Hydrocortisone / blood* Male Psychiatric Status Rating Scales Schizophrenia / blood* Vitamin B 12 / blood* Young Adult |
| Chemical | |
Reg. No./Substance:
|
25167-62-8/Docosahexaenoic Acids; 454-28-4/Homocysteine; 50-23-7/Hydrocortisone; 59-30-3/Folic Acid; 68-19-9/Vitamin B 12 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Genetic polymorphisms in the treatment of depression: Speculations from an augmentation study using ...
Next Document: Childhood sexual interactions with other children are associated with lower preferred age of sexual ...